Eco-Friendly UV Spectrophotometric Method for Simultaneous Estimation of Evogliptin and Metformin Hydrochloride in Bulk and Combined Tablet Dosage Form

IF 1.1 Q4 CHEMISTRY, ANALYTICAL

Brazilian Journal of Analytical Chemistry Pub Date : 2022-08-01 DOI:10.30744/brjac.2179-3425.ar-47-2022

N. Agrawal, Shilpi Pathak

{"title":"Eco-Friendly UV Spectrophotometric Method for Simultaneous Estimation of Evogliptin and Metformin Hydrochloride in Bulk and Combined Tablet Dosage Form","authors":"N. Agrawal, Shilpi Pathak","doi":"10.30744/brjac.2179-3425.ar-47-2022","DOIUrl":null,"url":null,"abstract":"Evogliptin (EGT) is used in fixed-dose combination with metformin hydrochloride (MFH) for a better glycemic control in Type 2 diabetes mellitus. To date, no method is available for simultaneous estimation of these drugs. In the present study, an UV spectrophotometric method was developed in distilled water, an environment-friendly solvent using the simultaneous equation technique to simultaneously determine EGT and MFH in bulk and tablet dosage form. The developed method was validated and applied to commercial tablet dosage forms containing EGT and MFH in combination. With a great correlation value (R2>0.998), the analytes displayed good linearity in the range of 10-100 μg mL-1. The low percent relative standard deviation proved the methods' precision. The methods' accuracy was demonstrated by excellent recovery. Thus, the developed method was found to be simple, environment-friendly, fast, specific, precise, and accurate, and it may be effectively used for routine analysis of EGT and MFH in bulk and their combined tablet dosage form.","PeriodicalId":9115,"journal":{"name":"Brazilian Journal of Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brazilian Journal of Analytical Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30744/brjac.2179-3425.ar-47-2022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Evogliptin (EGT) is used in fixed-dose combination with metformin hydrochloride (MFH) for a better glycemic control in Type 2 diabetes mellitus. To date, no method is available for simultaneous estimation of these drugs. In the present study, an UV spectrophotometric method was developed in distilled water, an environment-friendly solvent using the simultaneous equation technique to simultaneously determine EGT and MFH in bulk and tablet dosage form. The developed method was validated and applied to commercial tablet dosage forms containing EGT and MFH in combination. With a great correlation value (R2>0.998), the analytes displayed good linearity in the range of 10-100 μg mL-1. The low percent relative standard deviation proved the methods' precision. The methods' accuracy was demonstrated by excellent recovery. Thus, the developed method was found to be simple, environment-friendly, fast, specific, precise, and accurate, and it may be effectively used for routine analysis of EGT and MFH in bulk and their combined tablet dosage form.

查看原文本刊更多论文

环保型紫外分光光度法同时测定埃沃列汀和盐酸二甲双胍的含量

Evogliptin（EGT）与盐酸二甲双胍（MFH）以固定剂量联合使用，可更好地控制2型糖尿病的血糖。到目前为止，还没有同时估计这些药物的方法。在本研究中，采用联立方程技术，在环境友好的溶剂蒸馏水中建立了一种紫外分光光度法，同时测定散装和片剂剂型中的EGT和MFH。该方法得到了验证，并应用于含有EGT和MF H的商业片剂剂型。分析物在10-100μg mL-1范围内表现出良好的线性关系，相关值很大（R2>0.998）。较低的相对标准偏差证明了该方法的准确性。回收率高，准确度高。因此，所开发的方法简单、环保、快速、特异、准确，可有效地用于散装EGT和MFH及其组合片剂剂型的常规分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brazilian Journal of Analytical Chemistry CHEMISTRY, ANALYTICAL-

CiteScore

1.60

自引率

14.30%

发文量

期刊介绍： BrJAC is dedicated to the diffusion of significant and original knowledge in all branches of Analytical Chemistry, and is addressed to professionals involved in science, technology and innovation projects at universities, research centers and in industry.