Preparation, Characterization and Rheological Behavior of Glutathione-Chitosan Conjugates in Aqueous Media

IF 5.8 4区工程技术 Q1 MECHANICS

Applied Rheology Pub Date : 2019-01-01 DOI:10.1515/arh-2019-0010

Yhors Ciro, J. Rojas, Cristian J Yarce, Constain H. Salamanca

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引用次数: 3

Abstract

Abstract Glutathione-chitosan conjugates are adequate carriers for anticancer treatment due to their ability for inhibition of efflux pumps, improved mucoadhesivity and in-situ gelling. These conjugates were obtained via carbodiimide at different reaction times in order to get different thiolation degrees (i.e., 4.4!, 5.1! and 7.0!) and their behavior in aqueous media at a pH of 4, 5 and 6 was assessed by measurements of hydrodynamic diameter, zeta potential and rheological analyses at a pH ranging from 4 to 6. Data examination was conducted by principal component analysis (PCA) which in turn explained 73.1! of data variability. All samples showed a Newtonian flow and thiolation rendered materials with a highly pronounced temperature-dependent behavior and a gel-like structure. In turn, the phase shift angle was the most prominent rheological change especially at a pH of 5.0 and 6.0 due to the formation of disulfide bonds. The thiolation degree was the most influential factor and it was inversely related to particle charge and consistency index.

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谷胱甘肽-壳聚糖偶联物的制备、表征及其在水介质中的流变行为

摘要谷胱甘肽-壳聚糖缀合物具有抑制外排泵、提高黏附性和原位胶凝的能力，是抗癌治疗的理想载体。这些共轭物通过碳二亚胺在不同的反应时间得到，以得到不同的硫代化度(即4.4!, 5.1 !和7.0!)以及它们在pH值为4、5和6的水介质中的行为，通过测量流体动力直径、zeta电位和pH值为4至6的流变学分析来评估。通过主成分分析(PCA)对数据进行检验，从而解释了73.1!数据可变性。所有样品都显示出牛顿流和硫代渲染材料具有高度明显的温度依赖行为和凝胶状结构。在pH为5.0和6.0时，由于二硫键的形成，相移角是最显著的流变变化。硫代化程度是影响颗粒浓度的最大因素，与颗粒电荷和浓度指数呈负相关。

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来源期刊

Applied Rheology 物理-力学

CiteScore

3.00

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Applied Rheology is a peer-reviewed, open access, electronic journal devoted to the publication in the field of applied rheology. The journal provides the readers with free, instant, and permanent access to all content worldwide; and the authors with extensive promotion of published articles, long-time preservation, language-correction services, no space constraints and immediate publication.