Relationship between life events and serum uric acid in patients with hyperuricemia

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1000-6699.2020.02.007

Yiwen Ma, Haibing Chen

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Abstract

Objective To investigate the relationship between psychological stress related factors in life events and serum uric acid levels in patients with hyperuricemia. Methods The life events scale was used to qualitatively and quantitatively analyze the mental stimulation of 60 hyperuricemia patients. The laboratory analysis, as well as correlation analysis and multivariate regression analysis, were used to compare the general data and biochemical indicators of patients under different pressures. Results Patients with a total score of 20 or less on the life event scale were included in the low-pressure group, and the total score greater than 20 points in the high-pressure group. The highest frequency of positive and negative life events were outstanding achievement and stress in work and study. The frequency of gout attacks and cholesterol, triglyceride, serum creatinine, serum uric acid, and cortisol levels in the high-pressure group were significantly higher than those in the low-pressure group (P<0.05). The positive life event stimulation was positively correlated with cholesterol and triglyceride, and the negative life event stimulation was positively correlated with uric acid. In the multivariate linear regression analysis with serum uric acid as the dependent variable, the frequency of gout attacks and the stress group finally entered the regression model in the last year. The regression model had statistical significance F(2, 54)=27.765(P<0.01), adjusted R2=0.522. Conclusions In patients with hyperuricemia who are greatly stimulated in family life and work in life events, mental stress is related with elevated levels of cholesterol, triglycerides and serum uric acid. Elevated triglycerides and cholesterol are related to positive life events, and the rise of blood uric acid is related to negative life events. For patients with hyperuricemia, high-stress and frequent gouts are associated with higher levels of serum uric acid. Key words: Hyperuricemia; Life events; Psychological stress; Gout

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高尿酸血症患者生活事件与血清尿酸的关系

目的探讨生活事件中心理应激相关因素与高尿酸血症患者血清尿酸水平的关系。方法采用生活事件量表对60例高尿酸血症患者的心理刺激进行定性和定量分析。采用实验室分析、相关分析和多元回归分析对不同压力下患者的一般数据和生化指标进行比较。结果生活事件量表总分在20分以下的患者被纳入低压组，总分大于20分的患者被列入高压组。积极和消极生活事件发生频率最高的是工作和学习中的突出成就和压力。高压组痛风发作频率及胆固醇、甘油三酯、血清肌酐、血清尿酸、皮质醇水平均显著高于低压组（P<0.05），生活事件刺激阳性与胆固醇、甘油三酯呈正相关，生活事件激励阴性与尿酸呈正相关。在以血清尿酸为因变量的多元线性回归分析中，痛风发作频率和应激组在最近一年最终进入回归模型。回归模型具有统计学意义，F（2，54）=27.765（P＜0.01），校正后的R2=0.522。结论高尿酸血症患者在家庭生活和工作生活事件中受到极大刺激，精神压力与胆固醇、甘油三酯和血清尿酸水平升高有关。甘油三酯和胆固醇升高与积极生活事件有关，血尿酸升高与消极生活事件有关。对于高尿酸血症患者来说，高压力和频繁痛风与血清尿酸水平升高有关。关键词：高尿酸血症；生活事件；心理压力；痛风

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.