Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities

IF 3.1 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganics Pub Date : 2023-08-10 DOI:10.3390/inorganics11080331

Amanda A. Silva, S. C. L. Frajácomo, Á. Cruz, Kaio Eduardo Buglio, Daniele Daiane Affonso, M. C. Portes, A. Ruiz, J. D. de Carvalho, W. Lustri, D. Pereira, A. M. da Costa Ferreira, P. Corbi

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引用次数: 0

Abstract

The growth of antibiotic resistance is a matter of worldwide concern. In parallel, cancer remains one of the main causes of death. In the search for new and improved antiproliferative agents, one of the strategies is the combination of bioactive ligands and metals that are already consolidated in the synthesis of metallopharmaceutical agents. Thus, this work deals with the synthesis, characterization, and study of naproxen (Nap)-based complexes of copper(II) and platinum(II) as antiproliferative agents. The copper complex (Cu–Nap) presents a binuclear paddle-wheel structure in a 1 Cu:2 Nap:1 H2O molar composition, in which Cu(II) is bonded to the carboxylate oxygens from naproxenate in a bidentate bridging mode. The platinum complex (Pt–Nap) was identified as the square planar cis-[Pt(Nap)2(DMSO)2] isomer, in which Pt(II) is bonded to the carboxylate oxygen atom of Nap in a monodentate fashion. Both complexes were inactive against the Gram-positive and Gram-negative bacterial strains assessed. Pt–Nap presented low cytostatic behavior over a set of tumor cells, but good viability for normal cells, while Cu–Nap was cytotoxic against all cells, with a cytocidal activity against glioma tumor cells.

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Naproxenates铜（II）和铂（II）的合成、表征和抗增殖活性评价

抗生素耐药性的增长是全世界关注的问题。与此同时，癌症仍然是死亡的主要原因之一。在寻找新的和改进的抗增殖剂时，其中一种策略是将生物活性配体和金属结合起来，这些配体和金属已经在金属药物的合成中得到了巩固。因此，本工作涉及铜（II）和铂（II）的萘普生（Nap）基复合物作为抗增殖剂的合成、表征和研究。铜配合物（Cu–Nap）呈双核桨轮结构，摩尔组成为1 Cu:2Nap:1 H2O，其中Cu（II）以双齿桥接模式与萘普生的羧酸根氧键合。铂络合物（Pt–Nap）被鉴定为正方形平面顺式-Pt（Nap）2（DMSO）2]异构体，其中Pt（II）以单齿方式与Nap的羧酸盐氧原子结合。这两种复合物对所评估的革兰氏阳性和革兰氏阴性菌株均无活性。Pt–Nap对一组肿瘤细胞表现出较低的细胞抑制行为，但对正常细胞具有良好的生存能力，而Cu–Nap则对所有细胞具有细胞毒性，对神经胶质瘤肿瘤细胞具有细胞杀伤活性。

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来源期刊

Inorganics Chemistry-Inorganic Chemistry

CiteScore

2.80

自引率

10.30%

发文量

193

审稿时长

6 weeks

期刊介绍： Inorganics is an open access journal that covers all aspects of inorganic chemistry research. Topics include but are not limited to: synthesis and characterization of inorganic compounds, complexes and materials structure and bonding in inorganic molecular and solid state compounds spectroscopic, magnetic, physical and chemical properties of inorganic compounds chemical reactivity, physical properties and applications of inorganic compounds and materials mechanisms of inorganic reactions organometallic compounds inorganic cluster chemistry heterogenous and homogeneous catalytic reactions promoted by inorganic compounds thermodynamics and kinetics of significant new and known inorganic compounds supramolecular systems and coordination polymers bio-inorganic chemistry and applications of inorganic compounds in biological systems and medicine environmental and sustainable energy applications of inorganic compounds and materials MD