Oxygen Measurement in Microdevices.

IF 5.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Annual Review of Analytical Chemistry Pub Date : 2022-06-13 DOI:10.1146/annurev-anchem-061020-111458

S. Grist, K. Bennewith, K. Cheung

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引用次数: 2

Abstract

Oxygen plays a fundamental role in respiration and metabolism, and quantifying oxygen levels is essential in many environmental, industrial, and research settings. Microdevices facilitate the study of dynamic, oxygen-dependent effects in real time. This review is organized around the key needs for oxygen measurement in microdevices, including integrability into microfabricated systems; sensor dynamic range and sensitivity; spatially resolved measurements to map oxygen over two- or three-dimensional regions of interest; and compatibility with multimodal and multianalyte measurements. After a brief overview of biological readouts of oxygen, followed by oxygen sensor types that have been implemented in microscale devices and sensing mechanisms, this review presents select recent applications in organs-on-chip in vitro models and new sensor capabilities enabling oxygen microscopy, bioprocess manufacturing, and pharmaceutical industries. With the advancement of multiplexed, interconnected sensors and instruments and integration with industry workflows, intelligent microdevice-sensor systems including oxygen sensors will have further impact in environmental science, manufacturing, and medicine.

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微型设备中的氧测量。

氧气在呼吸和代谢中起着重要作用，在许多环境、工业和研究环境中，量化氧气水平至关重要。微型设备有助于实时研究动态氧依赖效应。这篇综述是围绕微型设备中氧气测量的关键需求组织的，包括微型制造系统的可积性；传感器动态范围和灵敏度；在二维或三维感兴趣区域上绘制氧气图的空间分辨测量；以及与多模式和多分析细胞测量的兼容性。在简要概述了氧气的生物读数，以及已在微型设备和传感机制中实现的氧气传感器类型之后，本综述介绍了芯片上器官体外模型的最新应用，以及实现氧气显微镜、生物工艺制造和制药行业的新传感器功能。随着多路复用、互连传感器和仪器的发展以及与行业工作流程的集成，包括氧传感器在内的智能微型设备传感器系统将在环境科学、制造业和医学领域产生进一步的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Analytical Chemistry CHEMISTRY, ANALYTICAL-SPECTROSCOPY

CiteScore

14.80

自引率

1.20%

发文量

期刊介绍： The Annual Review of Analytical Chemistry, launched in 2008, offers a comprehensive perspective on the field, drawing from diverse disciplines such as biology, physics, and engineering, with analytical chemistry as the central theme. The journal's current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.