Sulphated galactopyran derived from Gracilaria opuntia, a marine macroalgae restores the antioxidant metabolic enzymes during STZ induced diabetic rats

Abstract

In vitro antioxidant assays of FM4 were estimated by DPPH, ABTS, hydroxyl free radical and Nitric oxide free radical activities. FM4 was purified and characterized by 1H-NMR spectra and FTIR as sulphated galactopyran. Diabetes was induced intraperitonially by single dose of STZ (55 mg/kg body weight). FM4 was administrated orally (80, 100, 125 mg/kg BW) to diabetic rats for 60 days. The enzymatic and non-enzymatic antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST), lipid peroxidase (LPx), glutathione reduced (GSH), vitamin-C (VIT-C) and vitamin-E (VIT-E) levels were estimated. Glibenclamide was used as standard drug.