Study on Binding Effect of Extracted Mucilage from Bombax ceiba Plant Flower Petals for Tablet Formulation

IF 0.4 Q4 PHARMACOLOGY & PHARMACY
Santosh Bhadkariya
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Abstract

Aim: The objective of the present investigation was to extract the mucilage from flower petals of Bombax ceiba and explore its use as a promising excipient for Pharmaceutical preparation. The natural polymers have constantly a remarkable property which makes them particular from synthetic polymer and B. ceiba flower mucilage is one such model that shows increasingly important properties making it a helpful excipient for a wide scope of utilizations. Materials and Methods: The flowers of B. ceiba were collected from the Regional Ayurveda Research Institute for Drug Development, Gwalior region of India and were authenticated at the Botanical Survey of India, Central Regional Centre, Allahabad, U.P (Authentication voucher No. B.S.I/C.R.C/TECH./2018-19/559 with Accession No. 103976). B. ceiba flower petals mucilage is isolated by the microwave-assisted method and tablet prepared by experimental runs was designed by Design Expert 10.0.1 (Stat Ease. Inc.) software following full factorial method. 32 full factorial designs were applied for examining two variables (factors) at three levels with a minimum of nine runs. The tablets containing paracetamol as main active constituent were prepared with by a wet granulation method using isolated mucilage in different composition (F1-F9) or starch (F10) or PVP K 30 (F11) as internal binder. Results: The flow properties of the drug excipients mixture were studied in term of bulk density; tapped density; car’s index; and angle of repose to establish the flow property reflect the appropriateness of formulation. All tablet formulations batch evaluated for post-compression parameters have shown acceptable and within the Pharmacopoeial limits of results. The release characteristics of formulations were studied using tablet dissolution test apparatus is paddle type (USP type II) at 50 rpm. The cumulative percent drug release of formulations, i.e., F1, F2, F3, F4, F5, F6, F7, F8, F9, F10, and F11 was 91.31%, 92.67%, 94.22%, 88.83%, 90.36%, 91.11%, 90.54%, 92.11%, 93.98%, 78.66%, and 80.36%, respectively, in 60 min. The result justified that the effect of optimized formulation F3 is significantly more effective than starch and similar effect as synthetic polymer. Conclusions: The results suggest that B. ceiba mucilage could be useful as an alternative binding agent in tablets with better mechanical properties and release profile.
蚕豆花瓣黏液在片剂中的结合作用研究
目的:从木棉花瓣中提取粘液,探讨其作为一种有前景的药用辅料的应用。天然聚合物一直具有显著的性能,这使它们与合成聚合物不同,而木棉花粘液就是这样一种表现出越来越重要性能的模型,使其成为一种有助于广泛应用的赋形剂。材料和方法:木棉的花收集自印度瓜廖尔地区阿育吠陀药物开发区域研究所,并在印度植物调查局,中央区域中心,阿拉哈巴德,U.P进行了鉴定(鉴定凭证编号:B.S.I/C.R.C/TECHN./2018-19/559,登录号:103976)。通过微波辅助方法分离天花板花瓣粘液,并且通过实验运行制备的片剂由Design Expert 10.0.1(Stat Ease.股份有限公司)软件按照全因子法设计。采用32个全因子设计,在三个水平上检查两个变量(因子),至少运行9次。以不同组成的分离粘液(F1-F9)或淀粉(F10)或PVP K30(F11)为内粘结剂,采用湿法制粒法制备了以对乙酰氨基酚为主要活性成分的片剂。结果:从体积密度的角度研究了药物-辅料混合物的流动特性;振实密度;汽车指数;以及建立流动特性的休止角反映了配方的适当性。对压缩后参数进行批量评估的所有片剂配方均显示可接受,且在药典的结果范围内。使用桨式(USP II型)片剂溶出试验装置在50rpm下研究制剂的释放特性。配方F1、F2、F3、F4、F5、F6、F7、F8、F9、F10和F11在60分钟内的累积药物释放百分比分别为91.31%、92.67%、94.22%、88.83%、90.36%、91.11%、90.54%、92.11%、93.98%、78.66%和80.36%。结论:该结果表明,木棉粘液可作为片剂的替代结合剂,具有更好的力学性能和释放特性。
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来源期刊
Asian Journal of  Pharmaceutics
Asian Journal of Pharmaceutics PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
47
期刊介绍: Character of the publications: -Pharmaceutics and Pharmaceutical Technology -Formulation Design and Development -Drug Discovery and Development Interface -Manufacturing Science and Engineering -Pharmacokinetics, Pharmacodynamics, and Drug Metabolism -Clinical Pharmacology, General Medicine and Translational Research -Physical Pharmacy and Biopharmaceutics -Novel Drug delivery system -Biotechnology & Microbiological evaluations -Regulatory Sciences
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