High drug loading polymer micelle@ZIF-8 hybrid core—shell nanoparticles through donor—receptor coordination interaction for pH/H2O2-responsive drug release

IF 2.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Frontiers of Materials Science Pub Date : 2022-06-20 DOI:10.1007/s11706-022-0600-1

Yikun Jiang, Zhentao Lei, Zaizai Tong

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引用次数: 4

Abstract

Smart drug delivery nanocarriers with high drug loading capacity are of great importance in the treatment of diseases, and can improve therapeutic effectiveness as well as alleviate side effects in patients. In this work, a pH and H₂O₂-responsive drug delivery platform with high doxorubicin (DOX) loading capacity has been established through coordination interaction between DOX and phenylboronic acid containing block polymer. A composited drug nanocarrier is further fabricated by growing a zeolitic imidazolate framework 8 (ZIF-8) on the surface of drug-loaded polymer micelles. The study verifies that ZIF-8 shell can act as intelligent “switch” to prevent DOX leaking from core-shell nanoparticles upon H₂O₂ stimulus. However, a burst drug release is detected upon pH and H₂O₂ stimuli due to the further disassociation of ZIF-8 in acid solution. Moreover, the in vitro anti-cancer experiments demonstrate that the DOX-loaded core—shell nanoparticles provide effective treatment towards cancer cells but have negligible effect on normal cells, which results from the high concentration of H₂O₂ and low pH in the microenvironment of tumor cells.

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高载药聚合物micelle@ZIF-8杂化核壳纳米粒子通过供体-受体配位相互作用实现pH/ h2o2反应性药物释放

具有高载药能力的智能给药纳米载体在疾病治疗中具有重要意义，可以提高治疗效果，减轻患者的副作用。本研究通过DOX与含苯硼酸的嵌段聚合物的配位相互作用，建立了pH和h2o2响应的高负载DOX的给药平台。通过在载药聚合物胶束表面生长咪唑酸分子筛骨架8 (ZIF-8)，进一步制备了复合药物纳米载体。研究验证了ZIF-8壳可以作为智能“开关”，在H2O2刺激下防止DOX从核壳纳米颗粒泄漏。然而，在pH和H2O2刺激下，由于ZIF-8在酸溶液中进一步解离，可以检测到药物释放的爆发。此外，体外抗癌实验表明，负载dox的核壳纳米颗粒对癌细胞具有有效的治疗作用，但对正常细胞的影响可以忽略不计，这与肿瘤细胞微环境中高浓度的H2O2和低pH有关。

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来源期刊

Frontiers of Materials Science MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

4.20

自引率

3.70%

发文量

515

期刊介绍： Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community. The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to): Biomaterials including biomimetics and biomineralization; Nano materials; Polymers and composites; New metallic materials; Advanced ceramics; Materials modeling and computation; Frontier materials synthesis and characterization; Novel methods for materials manufacturing; Materials performance; Materials applications in energy, information and biotechnology.