Efficiency of immunomodulatory therapy in the complex treatment of patients with combined craniofacial injuries

Abstract

Background: Our aim is to study the effectiveness of immunomodulatory therapy with Polyoxidonium in the complex treatment of patients with combined craniofacial injuries. Methods: In accordance with the intended purpose of this study, we conducted a comprehensive immunological examination of patients with combined craniofacial injuries in the dynamics of treatment with the drug authorized for use in healthcare practice: Polyoxidonium. In total 22 patients with combined craniofacial injuries in the complex therapy received Polyoxidonium at a dosage level of 6[Formula: see text]mg/m once for 5 days. Results: We conducted a comprehensive immunological study of the clinical course of the post-traumatic period in patients with combined craniofacial injuries which showed that the immunomodulatory therapy with Polyoxidonium during the complex treatment has a high clinical and immunological efficacy. Conclusions: Thus, in patients with combined craniofacial injuries, there is an immunodeficiency state involving both cellular immunity, manifested by a decrease in the level of T-lymphocytes, T-helpers, NK-cells and B-lymphocytes, and decrease of immunoglobulin production. The use of Polyoxidonium immunomodulator in complex therapy in patients with combined craniofacial injuries helped in improving the condition of patients in a shorter period of time and in preventing the development of purulent-inflammatory complications due to the positive dynamics of cellular and humoral immunity.