Controllable blood–brain barrier (BBB) regulation based on gigahertz acoustic streaming

IF 3.5 3区工程技术 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nami Jishu yu Jingmi Gongcheng/Nanotechnology and Precision Engineering Pub Date : 2022-12-01 DOI:10.1063/10.0014861

Hang Qi, ShuaiHua Zhang, Jiaxue Liang, Shan He, Yanyan Wang

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引用次数: 2

Abstract

The blood–brain barrier (BBB) is a structural and functional barrier necessary for brain homeostasis, and it plays an important role in the realization of neural function and in protecting the brain from damage by circulating toxins and pathogens. However, the extremely dense BBB also severely limits the transport of molecules across it, which is a great hindrance to the diagnosis and treatment of central nervous system (CNS) diseases. This paper reports a new method for controllable opening of the BBB, based on the gigahertz acoustic streaming (AS) generated by a bulk acoustic wave resonant device. By adjusting the input power and working distance of the device, AS with tunable flow rate can be generated to disrupt tight junction proteins (TJs) between endothelial cells. The results obtained with this method show that the gigahertz AS promotes the penetration of dextran molecules with different molecular weights across the BBB. This work provides a new platform for studying the mechanical regulation of BBB by fluid shear forces and a new method for improving the efficiency of drug delivery.

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基于千兆赫声流的可控血脑屏障(BBB)调节

血脑屏障（BBB）是大脑稳态所必需的结构和功能屏障，在实现神经功能和保护大脑免受循环毒素和病原体损伤方面发挥着重要作用。然而，极其密集的血脑屏障也严重限制了分子在血脑屏障中的运输，这对中枢神经系统（CNS）疾病的诊断和治疗是一个巨大的障碍。本文报道了一种基于体声波谐振装置产生的千兆赫声流（AS）的可控开启BBB的新方法。通过调节设备的输入功率和工作距离，可以产生具有可调流速的AS，以破坏内皮细胞之间的紧密连接蛋白（TJs）。用这种方法获得的结果表明，千兆赫AS促进了具有不同分子量的右旋糖酐分子穿过血脑屏障。这项工作为研究流体剪切力对血脑屏障的机械调节提供了一个新的平台，也为提高药物递送效率提供了一种新的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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