Comparison of 18F-Flurpiridaz and 13N-NH3·H2O PET/CT myocardial perfusion imaging in animal experiments

中华核医学与分子影像杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2020.02.003

Jiao Wang, Shuai Li, Tian-wen Liu, Jie-min Zhang, Yue Chen

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Abstract

Objective To explore the biodistribution and quantitative value of 18F-Flurpiridaz in mini-swine, and compare with 13N-NH3·H2O. Methods Ten Bama mini-swine were divided into normal group and myocardial infarction group (n=5 in each group). Normal group was not treated and myocardial infarction group was modeled by thoracotomy and coronary artery ligation. Both groups were preceded by 13N-NH3·H2O imaging, followed by 18F-Flurpiridaz imaging (time interval >40 min). Injection dosage of 2 tracers was the same (185-370 MBq). 18F-Flurpiridaz whole-body PET/CT imaging was also performed in normal group. Biological distribution of 18F-Flurpiridaz was observed, and the ratio of radioactive uptake of 18F-Flurpiridaz between myocardium and adjacent tissues or organs was calculated. Image quality score and rest myocardial blood flow (rMBF) of 2 imaging tracers in normal group were measured and compared. MPI image quality score, cardiac function parameters such as summed rest score (SRS), myocardial infarction area percentage, total perfusion defect (TPD), and left ventricular ejection fraction (LVEF) of 2 imaging tracers were compared in myocardial infarction group. Data was analyzed by paired t test. Results In normal group, 18F-Flurpiridaz in the myocardium was clearly observed, with high radioactive uptake maintaining within 2 h postinjection. The radioactivity count ratios of left ventricular myocardium to cardiac pool, the lungs and liver were high (5.19-12.87, 4.17-50.51, 2.08-6.92). The quality of 18F-Flurpiridaz MPI images in both groups was excellent (10/10). The rMBF (ml·g-1·min-1) in different regions of left ventricle measured by 18F-Flurpiridaz and 13N-NH3·H2O imaging were not significantly different (left anterior descending: 0.98±0.06 vs 0.92±0.13; left circumflex: 0.98±0.05 vs 0.88±0.12; right coronary artery: 0.95±0.07 vs 0.88±0.15; left ventricle: 0.96±0.07 vs 0.90±0.13; t values: from -1.70 to -0.90, all P>0.05). There was no significant difference in SRS, myocardial infarction area percentage, TPD, rMBF or LVEF between 18F-Flurpiridaz and 13N-NH3·H2O (SRS: 10.6±4.1 vs 9.2±4.6; myocardial infarction area percentage: (15.2±9.0)% vs (12.6±6.6)%; TPD: (11.6±6.3)% vs (9.6±3.9)%; LVEF: (68.6±11.1)% vs (71.4±11.3)%; t values: -2.33-2.75, all P>0.05). Conclusions Comparing with 13N-NH3·H2O, 18F-Flurpiridaz has the advantages of good MPI image quality, accurate measurement of cardiac function parameters and quantitative potential of myocardial blood flow, which make it as a promising positron myocardial perfusion imaging agent. Key words: Myocardial perfusion imaging; Pyridazines; Fluorine radioisotopes; Ammonia; Positron-emission tomography; Tomography, X-ray computed; Swine

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18F-氟吡唑与13N-NH3·H2O PET/CT心肌灌注显像的动物实验比较

目的探讨18f -氟吡达滋在小型猪体内的生物分布及定量价值，并与13N-NH3·H2O进行比较。方法选取巴马迷你猪10头，分为正常组和心肌梗死组，每组5头。正常组不治疗，心肌梗死组采用开胸结扎造模。两组均先行13N-NH3·H2O显像，后行18f -氟吡唑显像(时间间隔bb0 ~ 40min)。两种示踪剂的注射剂量相同(185 ~ 370 MBq)。正常组行18f -氟吡达全身PET/CT成像。观察18f -氟吡达的生物分布，计算心肌与邻近组织或器官对18f -氟吡达的放射性摄取比。比较正常组2种显像示踪剂的图像质量评分和静息心肌血流量(rMBF)。比较2种显像示踪剂在心肌梗死组的MPI图像质量评分、心功能参数如总休息评分(SRS)、心肌梗死面积百分比、总灌注缺损(TPD)、左室射血分数(LVEF)。数据分析采用配对t检验。结果在正常组，18f -氟吡达在心肌中明显可见，注射后2 h内仍保持高放射性摄取。左室心肌与心池、肺、肝的放射性计数比较高(5.19 ~ 12.87、4.17 ~ 50.51、2.08 ~ 6.92)。两组18F-Flurpiridaz MPI图像质量均为极好(10/10)。18f -氟吡达和13N-NH3·H2O成像测量左心室不同区域的rMBF (ml·g-1·min-1)无显著差异(左前降:0.98±0.06 vs 0.92±0.13;左旋:0.98±0.05 vs 0.88±0.12;右冠状动脉:0.95±0.07 vs 0.88±0.15;左心室:0.96±0.07 vs 0.90±0.13;t值为-1.70 ~ -0.90,P值均为0.05)。18f -氟吡达与13N-NH3·H2O在SRS、心肌梗死面积百分比、TPD、rMBF或LVEF方面无显著差异(SRS: 10.6±4.1 vs 9.2±4.6;心肌梗死面积百分比:(15.2±9.0)% vs(12.6±6.6)%;TPD:(11.6±6.3)% vs(9.6±3.9)%;LVEF:(68.6±11.1)% vs(71.4±11.3)%;t值为-2.33-2.75,P值均为0.05)。结论与13N-NH3·H2O相比，18F-Flurpiridaz具有MPI图像质量好、心功能参数测量准确、心肌血流定量电位等优点，是一种很有前景的正电子心肌灌注显像剂。关键词:心肌灌注成像;邻二氮杂苯;氟放射性同位素;氨;正电子发射断层扫描;断层扫描，x射线计算机;猪

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

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发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.