Combination of Vestibular Rehabilitation and Galvanic VestibularStimulation ImprovesVerbal andVisuospatial Memory: A Randomized Control Trial in Patients with Amnestic Mild Cognitive Impairment

IF 0.4 Q4 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Auditory and Vestibular Research Pub Date : 2023-06-18 DOI:10.18502/avr.v32i3.12933

Behnoush Kamali, M. A. Ghahraman, Reza Hoseinabadi, V. Aghamollaii, S. Jalaie

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Abstract

Background and Aim: Considering the critical input of the vestibular system to the hippocampus as an area involved in cognition, and vestibular disorders reported in patients with amnestic Mild Cognitive Impairment (aMCI), we aimed to investigate the effects of Vestibular Rehabilitation (VR) with and without noisy Galvanic Vestibular Stimulation (nGVS) on cognitive function in patients with aMCI. Methods: In a randomized controlled trial, twenty-two patients with aMCI were randomly assigned to two groups receiving: 1) VR for four weeks (VR group); 2) VR for four weeks with nGVS for three sessions (GVS+VR group). Outcome measures were Rey's Auditory-Verbal Learning Test (RAVLT), Corsi blocks, Visual Search (VS), and match to sample tests. Results: Mean immediate and delayed recalls of RAVLT, all of the outcomes of Corsi blocks and VS tests, and the error rate of the match to sample tests improved significantly after intervention in VR and GVS+VR groups. Between-group differences were observed for learning and delayed recalls of RAVLT (p=0.001, d=0.444 and p<0.001, d=0.512 respectively), reaction times 1 and 2 in VS (p=0.007, d=0.325 and p=0.001, d=0.446 respectively), the total correct trial of Corsi blocks (p=0.026, d=0.235), and error rate of the match to sample (p=0.017, d=0.266) tests. Conclusion: The synergistic effect of VR and GVS suggested that simultaneous use of both stimulations improves verbal and visuospatial memory in aMCI patients. Study protocol location: https://irct.ir/trial/47249 Trial registration number: IRCT20160131026279N3 Keywords: Mild cognitive impairment; spatial memory; verbal memory; hippocampus; galvanic vestibular stimulation; vestibular rehabilitation

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前庭康复和前庭电刺激相结合改善言语和视觉空间记忆：一项针对失聪轻度认知障碍患者的随机对照试验

背景和目的：考虑到前庭系统对海马体的关键输入是一个涉及认知的区域，以及遗忘性轻度认知障碍（aMCI）患者的前庭障碍，我们旨在研究有无噪声前庭电刺激（nGVS）的前庭康复（VR）对aMCI患者认知功能的影响。方法：在一项随机对照试验中，22名aMCI患者被随机分为两组：1）VR组，为期四周（VR组）；2） VR为期四周，nGVS为期三次（GVS+VR组）。结果测量是Rey的听觉言语学习测试（RAVLT）、Corsi块、视觉搜索（VS）和匹配样本测试。结果：干预VR组和GVS+VR组后，RAVLT的平均即时和延迟回忆、Corsi块和VS测试的所有结果以及与样本测试匹配的错误率显著改善。在学习和延迟回忆RAVLT方面观察到组间差异（分别为p=0.001，d=0.444和p<0.001，d=0.512），VS中的反应时间1和2（分别为p=0.007，d=0.325和p=0.001，d=0.446），Corsi块的总正确性试验（p=0.026，d=0.235），以及样本匹配测试的错误率（p=0.017，d=0.266）。结论：VR和GVS的协同作用表明，同时使用这两种刺激可以改善aMCI患者的言语和视觉空间记忆。研究方案位置：https://irct.ir/trial/47249试验注册号：IRCT20160131026279N3关键词：轻度认知障碍；空间记忆；言语记忆；海马；前庭电流刺激；前庭康复

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