The Hazard index at thirty-seven: New science new insights

IF 6.1 Q1 TOXICOLOGY

Current Opinion in Toxicology Pub Date : 2023-06-01 DOI:10.1016/j.cotox.2023.100388

Paul S. Price

引用次数: 2

Abstract

The Hazard Index (HI) was developed as a quantitative tool for characterizing noncancer risks from combined exposures. HI, and related approaches, dominate assessments of such risks. Despite this dominance, HI has limitations: the widespread lack of data required to use the tool; the inability to deal with synergy and potentiation; and the inability to quantitatively predict the probability of specific adverse effects. This article provides a review of recent advancements in toxicology and exposure science and their implications for HI. The new findings illuminate aspects of the HI and reduce the limitations of using the tool.

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危险指数在37:新的科学新的见解

危害指数(HI)是一种定量工具，用于描述联合暴露的非癌症风险。HI和相关方法主导着此类风险的评估。尽管占据主导地位，但HI也有其局限性:普遍缺乏使用该工具所需的数据;不能处理协同和增强;以及无法定量预测特定不良反应的概率。本文综述了毒理学和暴露科学的最新进展及其对HI的影响。新的发现阐明了HI的各个方面，并减少了使用该工具的局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Toxicology Pharmacology, Toxicology and Pharmaceutics-Toxicology

CiteScore

10.40

自引率

0.00%

发文量

期刊介绍： The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.