Analysis of risk factors for susceptibility of abnormal liver function in male patients with gout

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1000-6699.2020.02.002

Tian Liu, R. Sun, Xiaoyu Cheng, Lidan Ma, Ying Xin, Zhao-tong Jia, Ying Chen, Qing Wang, Changgui Li

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Abstract

Objective To investigate the risk factors for susceptibility of abnormal liver function in patients with gout. Methods A total of 5 044 cases of male gout patients in remission were selected and divided into normal liver function group with 3 693 patients and abnormal liver function group with 1 351 patients. The clinical information was collected and relevant biochemical indices were detected. Serum uric acid(SUA) was divided into quartiles, and its associations with elevated ALT were evaluated. Results There were significant differences in the history of drinking, family history, combining with hyperlipidemia, fatty liver, and coronary heart disease between the abnormal liver function group and normal function group(P 0.05). Further logistic regression analysis indicated that body mass, waist circumference, combining fatty liver, higher SUA level, higher cholesterol and triglyceride were risk factors of the early onset of abnormal liver function. ALT and the proportion of abnormal liver function were increased with the increase of UA. After adjustment for BMI, TG, TC and fatty liver, the ALT level and the proportion of abnormal liver function decreased significantly while still showed an upward trend. Conclusion Patients with obesity, high level of uric acid, high blood lipids and fatty liver were more likely to develop abnormal liver function, SUA was independently associated with elevated ALT. Key words: Gout; Liver transaminases; Risk factors

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男性痛风患者肝功能异常易感性的危险因素分析

目的探讨痛风患者肝功能异常易感性的危险因素。方法选择5 044例男性痛风缓解期患者，分为肝功能正常组3 693例和肝功能异常组1 351例。收集临床资料，检测相关生化指标。将血清尿酸（SUA）分为四分位数，并评估其与ALT升高的关系。结果肝功能异常组与正常组在饮酒史、家族史、合并高脂血症、脂肪肝、冠心病等方面存在显著性差异（P＜0.05），较高的胆固醇和甘油三酯是肝功能异常早期发病的危险因素。ALT和肝功能异常的比例随着UA的增加而增加。调整BMI、TG、TC和脂肪肝后，ALT水平和肝功能正常的比例显著下降，但仍呈上升趋势。结论肥胖、高尿酸、高血脂和脂肪肝患者更容易发生肝功能异常，SUA与ALT升高独立相关；肝转氨酶；风险因素

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.