Potential utilization of neopterin measurements in the assessment of pyrexia in metastatic melanoma treated with combined targeted therapy: a case report

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2020-01-01 DOI:10.1515/pteridines-2020-0009

M. Bartoušková, Michaela Hrouzková, F. Čtvrtlík, P. Petrová, N. Rušarová, K. Kučerová, Andrea Vernerová, B. Melichar, H. Študentová

引用次数: 1

Abstract

Abstract In patients with metastatic melanoma the advent of targeted therapy and immune checkpoint inhibitors has transformed the management of advanced and metastatic disease, resulting in improved outcomes. Neopterin is a biomarker of immune activation increased in cancer as well as in other conditions associated with immune activation. We present a case of a patient with advanced metastatic melanoma responding to the combination targeted therapy with dabrafenib and trametinib. The treatment was complicated by a fever that was accompanied by a marked rise in serum and urinary neopterin concentrations. Present case report illustrates not only the efficacy of combined targeted therapy, but also the utilization of neopterin measurements in the diagnosis and monitoring of pyrexia in patients with metastatic malignant melanoma.

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新蝶呤测量在评估联合靶向治疗转移性黑色素瘤发热中的潜在应用：一例报告

摘要在转移性黑色素瘤患者中，靶向治疗和免疫检查点抑制剂的出现改变了晚期和转移性疾病的管理，从而改善了预后。新蝶呤是癌症以及其他与免疫激活相关的疾病中免疫激活增加的生物标志物。我们报告了一例晚期转移性黑色素瘤患者对达非尼和曲美替尼联合靶向治疗有反应。治疗因发烧而复杂，并伴有血清和尿液中新蝶呤浓度的显著升高。目前的病例报告不仅说明了联合靶向治疗的疗效，还说明了新蝶呤测量在转移性恶性黑色素瘤患者发热诊断和监测中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.