Correlation Between Vitamin D3 and Fasting Blood Sugar in Type 2 Diabetes Mellitus Patients and Normal Individuals in a Bangladeshi Population

Abstract

Type 2 diabetes mellitus (T2DM) is a major global health problem. In 2013, there were 382 million people with diabetes; this number is estimated to grow to 592 million by 2035. The highest prevalence rates of T2DM are found in developing countries1. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and relative (or absolute) insulin deficiency2. In recent years, the influence of vitamin D on diabetes becomes a research interest – many studies paid attention to the relationship between vitamin D and insulin sensitivity and β-cell function. Some described that vitamin D is an important nutritional factor for type 2 diabetes mellitus pathogenesis by modulating insulin receptor gene expression and insulin secretion or through reninangiotensin aldosterone system3-6. Other studies claimed that low vitamin D impairs insulin synthesis, secretion resulting in glucose intolerance especially in type 2 Diabetes Mellitus (T2DM)7-10. However, in other studies, any correlations between vitamin D and T2DM were denied11,12. Hence, controversies still prevail on association of vitamin D level Abstract