Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment

IF 2.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Frontiers of Materials Science Pub Date : 2023-04-20 DOI:10.1007/s11706-023-0641-0

Fangling Li, Xiaoman Han, Dongdong Cao, Junxia Yin, Li Chen, Dongmei Li, Lin Cui, Zhiyong Liu, Xuhong Guo

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引用次数: 0

Abstract

Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents. In particular, the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage. In this study, gelatin (GN) and oxidized pectin (OP) were used for Schiff base cross-linking, and then polyvinyl alcohol (PVA) solution mixed with hemostatic caffeic acid (CA) was introduced to obtain aerogel substrate material (CB) after lyophilization. Polydimethylsiloxane (PDMS) and silver nanowires (Ag NWs) were used to construct a hydrophobic layer, an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation, antifouling, hemostasis and antibacterial properties (PDMS-Ag NW-CB). The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0, so that thermal energy loss from the body is minimized. The contact angles with water and blood are 129° and 120°, respectively, which have the effect of antifouling. This dressing can absorb blood quickly within 10 min, adhere to and gather platelets, and achieve hemostasis. It has good antibacterial and biocompatibility. Therefore, PDMS-Ag NW-CB has great potential in application to emergency treatment.

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急救用保温、防污、止血、抗菌气凝胶伤口敷料

多功能止血敷料在紧急事故的复杂情况下使用，优于现有的止血敷料。特别是现有敷料缺乏对大出血后低温休克预防的考虑。本研究以明胶(GN)和氧化果胶(OP)进行希夫碱交联，然后引入聚乙烯醇(PVA)溶液与止血咖啡酸(CA)混合，冻干后得到气凝胶底物(CB)。采用聚二甲基硅氧烷(PDMS)和银纳米线(Ag NWs)在CB两侧构建疏水层、抗菌层和红外反馈层，制备具有保温、防污、止血、抗菌功能的多功能气凝胶创面敷料(PDMS-Ag NW-CB)。结果表明，PDMS-Ag NW-CB的红外透过率几乎为0，使机体热能损失最小。与水和血液的接触角分别为129°和120°，具有防污作用。本敷料能在10分钟内迅速吸收血液，粘附并聚集血小板，达到止血的目的。具有良好的抗菌性和生物相容性。因此，PDMS-Ag NW-CB在应急处理中具有很大的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers of Materials Science MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

4.20

自引率

3.70%

发文量

515

期刊介绍： Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community. The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to): Biomaterials including biomimetics and biomineralization; Nano materials; Polymers and composites; New metallic materials; Advanced ceramics; Materials modeling and computation; Frontier materials synthesis and characterization; Novel methods for materials manufacturing; Materials performance; Materials applications in energy, information and biotechnology.