Methicillin-resistant Staphylococcus aureus in urinary tract infections; prevalence and antimicrobial resistance

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2021-07-04 DOI:10.34172/jrip.2022.08

Raghad Abdulsalam Khaleel, Narjes Alfuraiji, Balsam Waleed Hussain, M. F. Nassar, F. Ebrahimzadeh

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Abstract

Introduction: The newly-launched strain of the Staphylococcus aureus, methicillin-resistant S. aureus, is considered the most emerging bacterium in-hospital infections globally. Objectives: The current research focused on the prevalence and virulence features of methicillin-resistant S. aureus (MRSA) bacteria recovered from urinary tract infections (UTIs) cases. Patients and Methods: A total of 710 urine specimens were taken from hospitalized patients who suffered from UTIs. S. aureus was recovered from urine specimens using the microbial culture. S. aureus antimicrobial susceptibility was assessed toward oxacillin and cefoxitin antimicrobial disk to determine the MRSA strains. The polymerase chain reaction (PCR) assessed the distribution of antimicrobial resistance encoding genes. S. aureus antimicrobial resistance was evaluated by disk diffusion. Results: Fifty-five out of 710 (7.7%) urine specimens were positive for the MRSA bacteria. The uppermost antibiotic resistance was obtained against penicillin (100%), ceftaroline (100%), gentamicin (87.2%), erythromycin (76.3%), and ciprofloxacin (69.0%). BlaZ (100%) and tetK (85.4%) had the higher frequency amid examined antimicrobial resistance-encoding genes. Conclusion: The high prevalence of MRSA isolates harboring antimicrobial resistance-encoding genes in the UTIs suggests that diseases caused by them need more expansion healthcare monitoring with essential demand for novel antimicrobials.

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耐甲氧西林金黄色葡萄球菌尿路感染;流行情况和抗微生物药物耐药性

简介：新推出的金黄色葡萄球菌菌株，耐甲氧西林金黄色葡萄菌，被认为是全球最新出现的医院感染细菌。目的：目前的研究重点是从尿路感染（UTIs）病例中恢复的耐甲氧西林金黄色葡萄球菌（MRSA）的流行率和毒力特征。患者和方法：共从尿路感染住院患者身上采集710份尿液样本。使用微生物培养从尿液样本中回收金黄色葡萄球菌。评估金黄色葡萄球菌对苯唑西林和头孢西丁抗菌盘的耐药性，以确定MRSA菌株。聚合酶链式反应（PCR）评估了抗微生物耐药性编码基因的分布。采用纸片扩散法评价金黄色葡萄球菌的耐药性。结果：710份尿液标本中有55份（7.7%）MRSA细菌呈阳性。对青霉素（100%）、头孢他林（100%），庆大霉素（87.2%）、红霉素（76.3%）和环丙沙星（69.0%）的耐药率最高，BlaZ（100%）和tetK（85.4%）的耐药频率较高。结论：在尿路感染中携带抗微生物耐药性编码基因的MRSA分离株的高患病率表明，由它们引起的疾病需要更多的医疗保健监测，对新型抗微生物药物的需求至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.