Efficacy of different doses of botulinum toxin A injections on bromhidrosis in adolescents

中华医学美学美容杂志 Pub Date : 2019-08-15 DOI:10.3760/CMA.J.ISSN.1671-0290.2019.04.011

Demei Zhao, Yanan Jiang, Shu-qin Wang, P. Xu, D. Zheng, Jie Wu

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Abstract

Objective To explore the therapeutic effect of different doses of botulinum toxin A injections on bromhidrosis. Methods A total of 200 cases were divided into mild-to-moderate group (N=100) and severe group (N=100) based on the grade of bromhidrosis, and each group was further divided into two groups: low dose group (50 cases) were treated by botulinum toxin A injections (100 U) and high dose group (50 cases) were treated with 200 U for bilateral axillary. The total effective rate and recurrence rate in both groups were compared. Results In the mild to moderate group, after treatment for 3 months, the total effective rate of both groups had no statistical difference (P>0.05), and the same with recurrence rate in 6 months follow-up (P>0.05). In the severe group, after treatment for 3 months, the total effective rate of the high dose group (82%) was significantly higher than that of the low dose group (64%), with statistical significance (χ2=4.110, P<0.05). After 6 months follow-up, recurrence rate in the high dose group (22%) was significantly lower than that of the low dose group(46%), with statistical significance (χ2=6.417, P<0.05). Conclusions A suitable dose of botulinum toxin A can be selected based on the severity of bromhidrosis, which is a individualized therapy for cost savings and might have potential benefits for patients with osmidrosis. Key words: Bromidrosis; Botulinum toxins, type A; Dose-response relationship, drug; Treatment outcome; Disease classification

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不同剂量A型肉毒毒素注射治疗青少年腋臭的疗效观察

目的探讨不同剂量A型肉毒毒素注射液治疗腋臭的疗效。方法根据腋臭程度将200例患者分为轻度至中度组（N=100）和重度组（N=10 0），每组再分为两组：低剂量组（50例）注射肉毒杆菌毒素A（100 U），高剂量组（5 0例）注射200 U治疗双侧腋窝。比较两组的总有效率和复发率。结果轻中度组治疗3个月后，两组总有效率无统计学差异（P>0.05），随访6个月复发率相同（P>0.05）；重症组治疗3月后，高剂量组总有率（82%）显著高于低剂量组（64%），具有统计学意义（χ2=4.110，P<0.05）。随访6个月后，高剂量组复发率（22%）显著低于低剂量组（46%），具有统计学意义，这是一种节省成本的个性化治疗，可能对腋臭患者有潜在的益处。关键词：溴化物；A型肉毒毒素；剂量-反应关系，药物；治疗结果；疾病分类

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来源期刊

中华医学美学美容杂志

自引率

0.00%

发文量

4641

期刊介绍： "Chinese Journal of Medical Aesthetics and Cosmetology" is a high-end academic journal focusing on the basic theoretical research and clinical application of medical aesthetics and cosmetology. In March 2002, it was included in the statistical source journals of Chinese scientific and technological papers of the Ministry of Science and Technology, and has been included in the full-text retrieval system of "China Journal Network", "Chinese Academic Journals (CD-ROM Edition)" and "China Academic Journals Comprehensive Evaluation Database". Publishes research and applications in cosmetic surgery, cosmetic dermatology, cosmetic dentistry, cosmetic internal medicine, physical cosmetology, drug cosmetology, traditional Chinese medicine cosmetology and beauty care. Columns include: clinical treatises, experimental research, medical aesthetics, experience summaries, case reports, technological innovations, reviews, lectures, etc.