Ambroxol therapy for Parkinson’s disease: Systematic literature review

Q4 Medicine

Romanian Journal of Neurology/ Revista Romana de Neurologie Pub Date : 2023-06-30 DOI:10.37897/rjn.2023.2.1

Virgi Mayang Maharani, Ken Wirastuti, Meyvita Silviana, Naili Sofi Riasari

引用次数: 0

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease. The accumulation of α-synuclein protein in the basal ganglia is the underlying pathogenesis of PD. Genetic abnormalities are one of the predisposing factors for PD. PDs with GBA gene mutations have abnormalities coding for β-glucocerebrosidase (GCase) enzymes in lysosomes, which lead to increased accumulation of α-synuclein. Ambroxol has long been known as a therapy for airway disorders which also has antioxidant benefits. However, recently, there have been many experimental studies examining the benefits of ambroxol in neurodegenerative diseases, including PD. This study aims to examine experimental studies of ambroxol administration in PD.

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氨溴索治疗帕金森病:系统文献综述

帕金森病(PD)是第二常见的神经退行性疾病。α-突触核蛋白在基底节区的积累是PD的潜在发病机制。遗传异常是帕金森病的易感因素之一。GBA基因突变的pd患者溶酶体中β-葡萄糖脑苷酶(GCase)编码异常，导致α-突触核蛋白积累增加。长期以来，氨溴索一直被认为是一种治疗气道疾病的药物，它还具有抗氧化作用。然而，最近，有许多实验研究检查了氨溴索在神经退行性疾病(包括PD)中的益处。本研究旨在探讨氨溴索给药治疗帕金森病的实验研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Romanian Journal of Neurology/ Revista Romana de Neurologie Medicine-Neurology (clinical)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.