Analysis of Etiology and Clinical Characteristics of 1170 Patients with Symptomatic Epilepsy in Jianghan Plain

长江医药(英文) Pub Date : 2020-06-29 DOI:10.4236/ym.2019.42013

Yunyu Ding, Xianglin Cheng

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引用次数: 1

Abstract

Objective: The etiology, clinical manifestations and treatment of 1170 patients with symptomatic epilepsy were retrospectively analyzed and provided guidance for further treatment of symptomatic epilepsy. Method: A retrospective analysis of 1170 cases of symptomatic epilepsy admitted to the First Affiliated Hospital of Yangtze University from January 2013 to June 2018 was conducted to analyze the etiology, clinical manifestations and treatment of different age groups. Results: Symptomatic epilepsy is high in the elderly, and men are more than women. Among the 1170 patients with symptomatic epilepsy, there were 81 (6.9%) cases of brain injury, 721 (61.6%) cases of cerebrovascular disease, 223 (19.0%) cases of tumor, 59 (5.0%) cases of central nervous system infection, 33 (2.8%) cases of immune metabolic disease, 11 (0.9%) cases of drugs, 6 (0.5%) cases of cortical dysplasia, 6 (0.5%) cases of neurodegenerative disease, 4 (0.3%) cases of parasites, 4 (0.3%) cases of poisons, and 22 (1.9%) cases of other diseases. Among them, central nervous system infection and cerebrovascular disease ranked first among the patients aged 0 - 18 years, followed by immune metabolic diseases; cerebrovascular disease ranked first among the patients aged 19 - 39 years, followed by tumors and brain trauma; cerebrovascular disease ranked first among the patients aged 40 - 65 years, followed by tumors and brain trauma; cerebrovascular disease ranked first among the patients aged over 65 years, followed by tumors, among the types of seizures, 74 (6.3%) cases of tonic seizures, 68 (5.8%) cases of clonic seizures, 856 (73.2%) cases of tonic-clonic seizures, 27 (2.3%) cases of myoclonic seizures, 12 (1.0%) cases of absence seizures, 116 (9.9%) cases of complicated partial seizures, and 17 (1.5%) cases of partial seizures, in addition to the etiology, 795 (67.9%) cases of sodium valproate, 152 (13.0%) cases of carbamazepine, 56 (4.8%) cases of topiramate, 117 (10.0%) cases of levetiracetam, 23 (2.0%) cases of lamotrigine, and 27 (2.3%) cases of others were taken. Conclusion: In symptomatic epilepsy, different age groups have different causes. Among them, cerebrovascular disease, central nervous system infection, brain trauma, and brain tumor are the main causes. The most common type of seizures is the occurrence of tonic-clonic seizures. The most common drugs are sodium valproate and carbamazepine.

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江汉平原1170例症状性癫痫病因及临床特点分析

目的:回顾性分析1170例症状性癫痫患者的病因、临床表现及治疗方法，为进一步治疗症状性癫痫提供指导。方法:回顾性分析2013年1月至2018年6月在长江大学附属第一医院收治的1170例有症状性癫痫患者，分析不同年龄组的病因、临床表现及治疗方法。结果:老年症状性癫痫发生率高，男性多于女性。1170例有症状性癫痫患者中，脑损伤81例(6.9%)，脑血管疾病721例(61.6%)，肿瘤223例(19.0%)，中枢神经系统感染59例(5.0%)，免疫代谢性疾病33例(2.8%)，药物11例(0.9%)，皮质发育不良6例(0.5%)，神经退行性疾病6例(0.5%)，寄生虫4例(0.3%)，毒物4例(0.3%)，其他疾病22例(1.9%)。其中，0 ~ 18岁患者以中枢神经系统感染和脑血管疾病居首，其次为免疫代谢性疾病;19 ~ 39岁患者以脑血管疾病居首，其次为肿瘤和脑外伤;40 ~ 65岁患者以脑血管疾病居首，其次为肿瘤和脑外伤;65岁以上患者中以脑血管疾病居首，其次为肿瘤，发作类型中强直性发作74例(6.3%)，阵挛性发作68例(5.8%)，强直性-阵挛性发作856例(73.2%)，肌阵挛性发作27例(2.3%)，失神性发作12例(1.0%)，复杂部分性发作116例(9.9%)，部分性发作17例(1.5%)，除病因外，丙戊酸钠795例(67.9%)。卡马西平152例(13.0%)，托吡酯56例(4.8%)，左乙拉西坦117例(10.0%)，拉莫三嗪23例(2.0%)，其他27例(2.3%)。结论:不同年龄组的症状性癫痫病因不同。其中脑血管疾病、中枢神经系统感染、脑外伤、脑肿瘤是主要原因。最常见的发作类型是强直阵挛发作。最常见的药物是丙戊酸钠和卡马西平。

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长江医药(英文)

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104