Impact of Phytomolecules with Nanotechnology on the Treatment of Inflammation

Q2 Pharmacology, Toxicology and Pharmaceutics
Sonia Singh, Bhupesh C. Semwal, Himanshu Sharma, D. Sharma
{"title":"Impact of Phytomolecules with Nanotechnology on the Treatment of\nInflammation","authors":"Sonia Singh, Bhupesh C. Semwal, Himanshu Sharma, D. Sharma","doi":"10.2174/1573407219666230807150030","DOIUrl":null,"url":null,"abstract":"\n\nInflammation is a part of the biological response of body tissues against harmful stimuli,\nsuch as damaged cells, pathogens, irradiations, and toxic compounds. Numerous treatments, including anti-inflammatory drugs that treat the condition of inflammation, are available for its management. Because of the severe adverse effects associated with synthetic medications, phytotherapy\nmay be a promising and effective approach to treating inflammation. The therapeutic potential of\nherbs is due to their capacity to target a variety of inflammatory mediators, including chemokines,\ncytokines, nitric oxide, lipoxygenase, nuclear factor kappa-B, and arachidonic acid. Furthermore,\nnanomedicine may be a valuable and effective formulation approach for overcoming the drawbacks\nof phytoconstituents, such as their low bioavailability, high first-pass metabolism, and poor stability. The current manuscript provides a thorough description of many phytoconstituents and herbal\nplants that have great potential for treating inflammation-related diseases, as well as information on\ntheir limitations, drug formulations, and regulatory issues.\n","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Bioactive Compounds","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1573407219666230807150030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0

Abstract

Inflammation is a part of the biological response of body tissues against harmful stimuli, such as damaged cells, pathogens, irradiations, and toxic compounds. Numerous treatments, including anti-inflammatory drugs that treat the condition of inflammation, are available for its management. Because of the severe adverse effects associated with synthetic medications, phytotherapy may be a promising and effective approach to treating inflammation. The therapeutic potential of herbs is due to their capacity to target a variety of inflammatory mediators, including chemokines, cytokines, nitric oxide, lipoxygenase, nuclear factor kappa-B, and arachidonic acid. Furthermore, nanomedicine may be a valuable and effective formulation approach for overcoming the drawbacks of phytoconstituents, such as their low bioavailability, high first-pass metabolism, and poor stability. The current manuscript provides a thorough description of many phytoconstituents and herbal plants that have great potential for treating inflammation-related diseases, as well as information on their limitations, drug formulations, and regulatory issues.
纳米技术植物分子对炎症治疗的影响
炎症是机体组织对有害刺激(如受损细胞、病原体、辐射和有毒化合物)的生物反应的一部分。有许多治疗方法,包括治疗炎症的消炎药,可用于治疗炎症。由于与合成药物相关的严重副作用,植物疗法可能是治疗炎症的一种有希望和有效的方法。草药的治疗潜力是由于它们能够靶向多种炎症介质,包括趋化因子、细胞因子、一氧化氮、脂氧合酶、核因子κ b和花生四烯酸。此外,纳米药物可能是克服植物成分生物利用度低、首过代谢高、稳定性差等缺点的一种有价值和有效的配方方法。目前的手稿提供了许多具有治疗炎症相关疾病的巨大潜力的植物成分和草药的全面描述,以及它们的局限性,药物配方和监管问题的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Current Bioactive Compounds
Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.90
自引率
0.00%
发文量
112
期刊介绍: The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信