Paternal smoking is associated with an increased risk of pregnancy loss in a dose-dependent manner: a systematic review and meta-analysis

Nadia A. du Fossé M.D. , Marie-Louise P. van der Hoorn M.D., Ph.D. , Nina H. Buisman B.Sc. , Jan M.M. van Lith M.D., Ph.D. , Saskia le Cessie Ph.D. , Eileen E.L. O. Lashley M.D., Ph.D.
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引用次数: 1

Abstract

Objective

To study the association between paternal lifestyle factors in the preconception period and the risk of pregnancy loss.

Evidence Review

The Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines for systematic reviews and meta-analysis were followed. PubMed and Embase databases were searched up to August 2020. Original articles in English language addressing the relation between paternal exposure status in the preconception period and pregnancy loss were included. The paternal lifestyle factors examined were smoking, alcohol consumption, and body mass index. Studies that only examined exposure status during pregnancy (and not in the preconception period) and those that solely focused on pregnancy outcome after artificial reproductive technology were excluded. The qualitative risk of bias assessments was performed. Meta-analysis using a random-effects model was performed if sufficient data were available, with the risk of pregnancy loss as the primary outcome.

Results

The systematic search included 3,386 articles, of which 11 met the inclusion criteria. In a meta-analysis of 8 studies, paternal smoking of >10 cigarettes per day in the preconception period was found to be associated with an increased risk of pregnancy loss, after adjustment for maternal smoking status (1–10 cigarettes per day, 1.01; 95% confidence interval [CI], 0.97–1.06; 11–19 cigarettes per day, 1.12; 95% CI, 1.08–1.16; ≥20 cigarettes per day, 1.23; 95% CI, 1.17–1.29). No clear association was found between paternal alcohol consumption and pregnancy loss, based on 5 available studies. No studies were identified evaluating the association between paternal body mass index and spontaneous pregnancy loss.

Conclusion

Awareness of the association between paternal smoking in the preconception period and the risk of pregnancy loss should be raised. More well-designed studies are needed to further investigate the effects of other paternal lifestyle factors on the risk of pregnancy loss.

父亲吸烟与流产风险增加呈剂量依赖关系:一项系统综述和荟萃分析
目的探讨孕前期父亲生活方式因素与流产风险的关系。证据评价遵循系统评价和荟萃分析的首选报告项目指南。检索截止到2020年8月的PubMed和Embase数据库。收录了有关孕前期父亲接触状况与流产之间关系的英文原创文章。父亲的生活方式因素包括吸烟、饮酒和身体质量指数。仅检查怀孕期间(而不是孕前)暴露状况的研究以及仅关注人工生殖技术后妊娠结果的研究被排除在外。进行偏倚的定性风险评估。如果有足够的数据,使用随机效应模型进行荟萃分析,以流产风险为主要结局。结果系统检索到3386篇文献,其中11篇符合纳入标准。在一项包含8项研究的荟萃分析中,在调整了母亲吸烟状况后,发现孕前父亲每天吸烟10支与流产风险增加有关(每天1-10支,1.01;95%置信区间[CI], 0.97-1.06;每天11-19支烟,1.12支;95% ci, 1.08-1.16;≥20支/天,1.23;95% ci, 1.17-1.29)。根据现有的5项研究,没有发现父亲饮酒与流产之间有明确的联系。没有研究确定评估父亲体重指数和自然流产之间的关系。结论应提高对孕前期父亲吸烟与流产风险关系的认识。需要更多精心设计的研究来进一步调查其他父亲生活方式因素对流产风险的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
F&S reviews
F&S reviews Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology
CiteScore
3.70
自引率
0.00%
发文量
0
审稿时长
61 days
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