Screening nicotinamide in cosmetic and pharmaceutical products and nicotinic acid skin penetration from essential-oil formulations using attenuated total reflectance-infrared spectroscopy

IF 0.3 Q4 SPECTROSCOPY

Biomedical Spectroscopy and Imaging Pub Date : 2017-06-20 DOI:10.3233/BSI-150126

Lai-Hao Wang, Yu-Ping Lin, Yi-Chi Lin

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引用次数: 1

Abstract

The nicotinic acid derivatives such as nicotinamide in cosmetic and pharmaceutical products were screened by fast and nondestructively method, attenuated total reflectance-infrared (ATR-IR) spectroscopy. The effects of sixteen essential oils creams (clove, cassia bark, geraniom, eucalyptus, thyme, nutmeg, coriander seed, damask, petitgrain, melissa, melaleuca alternifolia (tea tree), grape fruit, verbena wild, cinnamon, sandal wood, ginger) on the skin permeation of nicotinic acid were studied using human skin by ATR-IR infrared spectroscopy. We selected essential oils creams based on the characteristic region (1493, 1260, 1050 and 824 cm−1) for nicotinic acid which were not interfered by essential oils. Although all essential oils creams enhanced the permeation of nicotinic acid, their effects were less than that of ethanol. Eucalyptus was found to be the most active, causing peak area decrease of C–H absorbances higher than the others. The effect of eucalyptus essential oil carriers on the release and percutaneous absorption of the nicotinic acid was studied in vitro using a permeation membrane model.

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使用衰减全反射-红外光谱技术筛选化妆品和医药产品中的烟酰胺以及精油配方中烟酸的皮肤渗透

采用衰减全反射-红外(ATR-IR)光谱法对化妆品和药品中的烟酰胺等烟酸衍生物进行了快速、无损的筛选。采用ATR-IR红外光谱法，研究了丁香、桂皮、天竺葵、桉树、百里香、肉豆蔻、香菜籽、绫、细粒、梅莉香、千层莲(茶树)、葡萄果、野生马尾草、肉桂、檀香、姜等16种精油乳膏对烟酸皮肤渗透的影响。我们根据烟酸的特征区域(1493、1260、1050和824 cm−1)选择精油面霜，这些区域不受精油的干扰。虽然所有的精油霜都能增强烟酸的渗透，但其效果不如乙醇。桉树是最活跃的，其C-H吸收峰面积下降幅度大于其他树种。采用透膜模型研究桉树精油载体对烟酸释放和经皮吸收的影响。

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Biomedical Spectroscopy and Imaging SPECTROSCOPY-

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期刊介绍： Biomedical Spectroscopy and Imaging (BSI) is a multidisciplinary journal devoted to the timely publication of basic and applied research that uses spectroscopic and imaging techniques in different areas of life science including biology, biochemistry, biotechnology, bionanotechnology, environmental science, food science, pharmaceutical science, physiology and medicine. Scientists are encouraged to submit their work for publication in the form of original articles, brief communications, rapid communications, reviews and mini-reviews. Techniques covered include, but are not limited, to the following: • Vibrational Spectroscopy (Infrared, Raman, Teraherz) • Circular Dichroism Spectroscopy • Magnetic Resonance Spectroscopy (NMR, ESR) • UV-vis Spectroscopy • Mössbauer Spectroscopy • X-ray Spectroscopy (Absorption, Emission, Photoelectron, Fluorescence) • Neutron Spectroscopy • Mass Spectroscopy • Fluorescence Spectroscopy • X-ray and Neutron Scattering • Differential Scanning Calorimetry • Atomic Force Microscopy • Surface Plasmon Resonance • Magnetic Resonance Imaging • X-ray Imaging • Electron Imaging • Neutron Imaging • Raman Imaging • Infrared Imaging • Terahertz Imaging • Fluorescence Imaging • Near-infrared spectroscopy.