Kinetics and mechanism of reduction of hexacholoroiridate (IV) by carcinogenic nicotine as alkaloid in aqueous solutions with determination of ionization constant of nicotine

IF 0.9 Q4 CHEMISTRY, PHYSICAL

Current Organocatalysis Pub Date : 2022-03-29 DOI:10.2174/2213337209666220329141541

R. Hassan, S. Ibrahim

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引用次数: 1

Abstract

Nicotine (NIC) is a lipid soluble alkaloid found predominately in tobacco and tobacco products including cigarettes, cigars and oral tobacco products such as snuff and chewing tobacco. Since nicotine substrate is the major constituent of tobacco smoke, it may cause negatively impacted problems to the human healthcare which keeps many users hooked. A spectrophotometric technique has been applied for investigating the kinetics of reduction of hexachloroiridiate (IV) as inert one-equivalent oxidant by carcinogenic nicotine (NIC) in aqueous perchlorate solutions. First-order in [IrCl6]2- and fractional-first-order with respect to the nicotine concentration has been revealed. Kinetic evidence for formation of 1: 1 intermediate complex between the NIC and [IrCl6]2- prior to the rate-determining step was confirmed. The ionization constants of nicotine was evaluated from the kinetic data and has been found to be 8.57x10-4 and 4.57 x 10-4 moldm-3 at ionic strength of 0.5 moldm-3 and at 30˚C and 40˚C, respectively. The activation parameters have been deduced from the kinetic results of the temperature-dependence of rate constants and a plausible reaction mechanism of the redox reaction is suggested and discussed. Nicotinic acid (Vitamin B3) was formed as oxidation product of nicotine oxidation.

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水溶液中致癌生物碱烟碱还原六氯铱酸盐（IV）的动力学和机理及烟碱电离常数的测定

尼古丁(NIC)是一种脂溶性生物碱，主要存在于烟草和烟草制品中，包括香烟、雪茄和口服烟草制品，如鼻烟和嚼烟。由于尼古丁底物是烟草烟雾的主要成分，它可能对人体健康造成负面影响，使许多使用者上瘾。采用分光光度法研究了致癌物质尼古丁(NIC)在高氯酸水溶液中还原惰性一当量氧化剂六氯iridiate (IV)的动力学。[IrCl6]2的一阶和分数一阶与尼古丁浓度的关系已被揭示。在速率决定步骤之前，NIC和[IrCl6]2-之间形成1:1中间配合物的动力学证据得到了证实。在离子强度为0.5 moldm-3和30℃、40℃条件下，尼古丁的电离常数分别为8.57 × 10-4和4.57 × 10-4 moldm-3。根据速率常数随温度变化的动力学结果推导出了活化参数，并对氧化还原反应的反应机理进行了讨论。烟酸(维生素B3)是尼古丁氧化的氧化产物。

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.