CNT based high-κ dielectric Ion Sensitive Field Effect Transistor Based Cholesterol Biosensor

Q3 Pharmacology, Toxicology and Pharmaceutics

Current Trends in Biotechnology and Pharmacy Pub Date : 2021-05-31 DOI:10.5530/CTBP.2021.2.20

Gaurav Keshwani, J. Dutta

引用次数: 0

Abstract

Carbon nanotube (CNT) based high-κ dielectric ion sensitive field effect transistor (ISFET) based cholesterol biosensor has been realized using Polyethylenimine (PEI) doped CNT channel and nanocomposite of potassium doped CNT with polypyrrole as sensing membrane.Device has been fabricated using solution method and electrical characterization of the device has been carried out after immobilization of enzyme cholesterol oxidase (ChOx) in presence of PBS solution.Device has shown a wide dynamic range (0.5 to 25mM), a good sensitivity of 60 mV/ decade,low response time (~1 s), low detection limit (0.23 mM), good stability (7 months) and high selectivity (interference ~1.8 %).

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基于碳纳米管的高κ介电离子敏感场效应晶体管胆固醇生物传感器

采用聚乙烯亚胺(PEI)掺杂碳纳米管通道和聚吡咯掺杂碳纳米管的纳米复合材料作为传感膜，实现了基于碳纳米管(CNT)的高κ介电离子敏感场效应晶体管(ISFET)的胆固醇生物传感器。采用溶液法制备了该装置，并在PBS溶液中固定化酶胆固醇氧化酶(ChOx)后对该装置进行了电学表征。器件具有动态范围宽(0.5 ~ 25mM)、灵敏度60mv / decade高、响应时间短(~1 s)、检出限低(0.23 mM)、稳定性好(7个月)、选择性高(干扰~ 1.8%)等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Trends in Biotechnology and Pharmacy Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： The Association of Biotechnology and Pharmacy (ABAP) will be useful to form a forum for scientists so that they can bring together to discuss and find scientific solutions to the problems of society. The annual meetings will help the members to share their knowledge and publish their research knowledge particularly by members and fellows of the Association and special care will be taken to provide an opportunity for young scientists. Besides this the association is planned to organize symposia, seminars and workshops on current developments of Biotechnology and Pharmacy particularly on the subject of current scientific interest, and the proceedings of which will be published regularly. And in view of the vast development of science and to disseminate the problems in publication of research work, an international journal of Current Trends in Biotechnology and Pharmacy has been started by ABAP.