Perinatal Mood and Anxiety Disorders in Women Undergoing Medically Assisted Reproduction

IF 1.2 Q4 PSYCHIATRY
A. Koukopoulos, L. De Chiara, Margherita Oresti, G. Kotzalidis, A. Viola, Margherita Di Giammarco, G. Sani, M. Bonito, G. Angeletti
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Abstract

Background: Women taking advantage of medically assisted reproduction (MAR) techniques may differ from spontaneously conceiving women (nonMAR) in risk of depression and/or anxiety. We aimed to investigate possible differences between MAR and nonMAR through the use of the Edinburgh Postnatal Depression Scale in a sample of Italian-speaking women at their third trimester of pregnancy. Methods: We administered the Edinburgh Postnatal Depression Scale (EPDS) to two groups of pregnant women, MAR and nonMAR, at the third trimester of pregnancy (T0), one month after delivery (T1), and three months after delivery (T2) from February 2013 to December 2019. EPDS total scores cutoffs were ≥9 for risk of depression, 9–11 mild depression, ≥12 major depression, and the EPDS-3A cluster ≥4 was a proxy for anxiety. Results: Included were 1303 nonMAR women and 92 MAR, an expected disproportion. NonMAR and MAR women did not differ on depression or anxiety at any assessment timepoint. MAR women were older than nonMAR, consumed more alcohol and medical drugs, and displayed more complications during pregnancy. Scoring over the threshold on depression risk was associated with foreign nationality, unemployment, psychiatric history of the patient, family or partner, psychiatric problems in past pregnancies, hyperemesis, premenstrual syndrome (PMS), and stressful life events in the last year at baseline, and, for some of them, at other timepoints. In contrast, MAR past or current was associated with having suprathreshold depression at the first-month postpartum follow-up. Conclusions: Taken together, our data show that women opting for MAR do not differ from spontaneously conceiving women regarding psychiatric outcomes but do differ on some sociodemographic and clinical variables.
接受医学辅助生殖的妇女的围产期情绪和焦虑症
背景:利用医学辅助生殖(MAR)技术的妇女在抑郁和/或焦虑风险方面可能与自然受孕妇女(非MAR)不同。我们的目的是通过使用爱丁堡产后抑郁量表在怀孕晚期讲意大利语的妇女样本中调查MAR和非MAR之间可能的差异。方法:2013年2月至2019年12月,对两组妊娠晚期(T0)、分娩后1个月(T1)和分娩后3个月(T2)的MAR和non - MAR孕妇实施爱丁堡产后抑郁量表(EPDS)。抑郁风险的EPDS总分截止值为≥9,轻度抑郁9 - 11分,重度抑郁≥12分,EPDS- 3a集群≥4为焦虑的代理。结果:纳入1303名非MAR妇女和92名MAR妇女,预期不成比例。在任何评估时间点上,NonMAR和MAR妇女在抑郁或焦虑方面没有差异。与非MAR女性相比,MAR女性年龄更大,饮酒和用药更多,在怀孕期间出现更多并发症。抑郁风险得分超过阈值与外国国籍、失业、患者、家人或伴侣的精神病史、过去怀孕期间的精神问题、呕吐、经前综合症(PMS)和去年基线的压力生活事件有关,对其中一些人来说,在其他时间点也是如此。相比之下,过去或现在的MAR与产后第一个月随访时的阈上抑郁有关。结论:综上所述,我们的数据表明,选择MAR的女性与自然受孕的女性在精神结局方面没有差异,但在一些社会人口学和临床变量上确实存在差异。
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来源期刊
CiteScore
1.90
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0.00%
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审稿时长
11 weeks
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