Herpes Virus Simple tipo 2 ¿factor y/o cofactor en el cáncer del cuello uterino? Revisión narrativa de la literatura

Abstract

Objective: To review and analyze the possible role of herpes simplex virus type 2 as a factor and/or cofactor in the origin and development of cervical cancer. Methods: The Latin American and international literature was reviewed between 1970 and Junio 2020. The terms were used:herpes simplex virus type 2 and/or epidemiology, human papillomavirus and cervical cancer. Results: Herpes simplex virus type 2 is considered one of the most frequent sexually transmitted infections in the world. It has been related to the origin and evolution of cervical neoplasms and their precursors. The possible mechanisms by which it could participate in the carcinogenesis of cervical cancer are analyzed, as a cofactor with papillomavirus or as an independent factor. Conclusions: More clinical, epidemiological, serological and molecular studies are required to elucidate the pathogenesis of herpes simplex virus type 2 in the carcinogenesis of cervical cancer