Structural, Morphological and Anti-bacterial Analysis of Nanohydroxyapatite Derived from Biogenic (SHELL) and Chemical Source: Formation of Apatite

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-03-10 DOI:10.22068/IJMSE.18.1.10

Chimmachandiran Suresh Kumar, K. Dhanaraj, R. Vimalathithan, P. Ilaiyaraja, G. Suresh

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引用次数: 4

Abstract

The Nano Hydroxyapatite (HAp), HAp/PEG and HAp/PVP powders derived from both Gastropod shell (natural source) and chemical precursor by the precipitation method were characterized through various characterization techniques such as FT-IR, XRD, SEM-EDX, TEM, Antibacterial activity and SBF analysis. Based on the structural, chemical, morphological and biological characteristics, HAp/PVP from natural and chemical precursors have been compared. Calculated structural parameters, crystallinity index, C/P ratio, morphology, antibacterial activity and SBF analysis of the products show that HAp/PVP-S (derived from a natural source) exhibits good mechanical property, rod like morphology, good antibacterial activity and apatite formation ability after 14 days. EDX analysis also shows the presence of carbon and sodium in HAp/PVP-S. Comparative analysis reveals that characteristics of HAp/PVP-S such as high carbonate content, low crystallite size, poor crystalline nature, presence of trace metal, non-stoichiometric elemental composition and rod like crystals which are matched with the characteristics of biological apatite. Thus, the HAp/PVP-S has the ability to form bone apatite.

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生物源和化学源纳米羟基磷灰石的结构、形态和抗菌分析:磷灰石的形成

通过FT-IR、XRD、SEM-EDX、TEM、抗菌活性和SBF分析等表征技术，对采用沉淀法从天麻壳（天然来源）和化学前体中制备的纳米羟基磷灰石（HAp）、HAp/PEG和HAp/PVP粉末进行了表征。基于结构、化学、形态和生物学特性，对天然和化学前驱体的HAp/PVP进行了比较。对产物的结构参数、结晶度指数、C/P比、形貌、抗菌活性和SBF分析表明，HAp/PVP-S（来源于天然）在14天后表现出良好的力学性能、棒状形貌、良好的抗菌活性和磷灰石形成能力。EDX分析还显示HAp/PVP-S中存在碳和钠。对比分析表明，HAp/PVP-S具有碳酸盐含量高、晶粒尺寸小、结晶性差、存在微量金属、元素组成不符合化学计量比、棒状晶体等特点，与生物磷灰石的特性相匹配。因此，HAp/PVP-S具有形成骨磷灰石的能力。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.