Anticancer potential of D-limonene and hispolon against colon cancer cell lines

Q3 Pharmacology, Toxicology and Pharmaceutics

Current Trends in Biotechnology and Pharmacy Pub Date : 2020-09-22 DOI:10.5530/CTBP.2020.3.31

K. C. Sekhar, Rajanikanth A. Rajanikanth, Md Nazneen Bobby, J. R. Kanala

引用次数: 1

Abstract

Natural products and associated combination therapy have gained prominent role in decreasing the adverse effects of synthetic drugs engaged in the severity of colon cancer. DLimonene a dietary monoterpene and hispolon a bioactive polyphenol proven to be anticancer agents independently against several cancers. The current study is designed to examine complimentary anticancer effect of D-limonenehispolonconcoction in COLO-205 and HCT-116 cell lines. Collectively, our cell viability, cell migration, clonogenic tests and CompuSyn analysis results exemplified that the combination of D-limonene and hispolonnatural products eminently effective against colon cancer cell lines.Gastric cancer patients are reported to develop severe side effects due to the currently available chemotherapy,our combinational anticancer therapy bydietary natural compounds would be highly beneficial to the patients.

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D-柠檬烯和hispolon对结肠癌细胞株的抗癌作用

天然产物和相关的联合治疗在减少合成药物对结肠癌严重程度的不良影响方面发挥了突出的作用。柠檬烯是一种膳食单萜，而组脂素是一种生物活性多酚，已被证明是抗癌剂，可以独立对抗几种癌症。目前的研究旨在检测d -柠檬烯-磷脂混合物对COLO-205和HCT-116细胞系的互补抗癌作用。总的来说，我们的细胞活力、细胞迁移、克隆性测试和CompuSyn分析结果表明，d -柠檬烯和组蛋白天然产物的组合对结肠癌细胞系非常有效。据报道，由于现有的化疗方法，胃癌患者产生了严重的副作用，我们的膳食天然化合物联合抗癌治疗将对患者非常有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Trends in Biotechnology and Pharmacy Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： The Association of Biotechnology and Pharmacy (ABAP) will be useful to form a forum for scientists so that they can bring together to discuss and find scientific solutions to the problems of society. The annual meetings will help the members to share their knowledge and publish their research knowledge particularly by members and fellows of the Association and special care will be taken to provide an opportunity for young scientists. Besides this the association is planned to organize symposia, seminars and workshops on current developments of Biotechnology and Pharmacy particularly on the subject of current scientific interest, and the proceedings of which will be published regularly. And in view of the vast development of science and to disseminate the problems in publication of research work, an international journal of Current Trends in Biotechnology and Pharmacy has been started by ABAP.