Quantitative analysis of optic disc structure and retinal nerve fiber layer thickness in patients with different degrees of Parkinson's disease

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-01-25 DOI:10.3760/CMA.J.ISSN.1005-1015.2020.01.004

Ying Zhao, Wei-jia Dai

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Abstract

Objective To observe the changes of optic disc structure and retinal nerve fiber layer thickness (RNFL) in patients with different degrees of Parkinson's disease (PD). Methods Thirty eyes of 30 patients with primary PD and 20 eyes of 20 healthy subjects (control group) in Xuanwu Hospital of Capital Medical University from October 2016 to October 2017 were enrolled in this study. The patients were divided into mild to moderate PD group (15 eyes of 15 patients) and severe PD group (15 eyes of 15 patients). All the patients underwent OCT examination. The optic disc area, cup area, C/D area ratio, rim volume, disc volume, cup volume, rim area, C/D area, linear C/D, vertical C/D, the thickness of average RNFL, superior, inferior, temporal upper (TU), superior temporal (ST), superior nasal (SN), nasal upper (NU), nasal lower (NL), inferior nasal (IN), inferior temporal (IT), temporal lower (TL) quadrant RNFL thickness. Analysis of variance was performed for comparison among three groups. Minimum significant difference t test was performed for comparison between two groups. Results Optic disc structure parameters: there was no significant difference in the area of optic disc between the three groups (F=1.226, P>0.05). The other optic disc parameters were significantly different in the three groups (F=5.221, 5.586, 6.302, 5.926, 5.319, 5.404, 5.861, 6.603; P 0.05). The average thickness of RNFL, TU, IN, IT and TL in patients of the mild to moderate PD group and severe PD group were less than that in the control group (P<0.05). The thickness of the average RNFL, TU, IN, IT and TL in patients of the severe PD group were less than that in the mild to moderate PD group (P<0.05). With the increase of PD severity, the RNFL of TL and TU thinned most significantly. Conclusions With the increase of the severity of PD, the optic disc structure and RNFL thickness changes obviously, showing reduced optic disc area and volume, enlarged cup area and volume significantly enlarged C/D ratio. The average RNFL thickness of PD patients is significantly thinner than that of the controls, and it is the most obvious in the TU and TL quadrant. Key words: Parkinson's disease; Optic disk; Nerve fibers; Tomography, optical coherence

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不同程度帕金森病患者视盘结构及视网膜神经纤维层厚度的定量分析

目的观察不同程度帕金森病（PD）患者视盘结构和视网膜神经纤维层厚度（RNFL）的变化。方法选择首都医科大学宣武医院2016年10月至2017年10月收治的原发性帕金森病患者30例30眼，健康对照组20例20眼。将患者分为轻度至中度PD组（15例15眼）和重度PD组（15%15眼）。所有患者均接受OCT检查。视盘面积、杯状物面积、C/D面积比、边缘体积、椎间盘体积、杯状物体积、边缘区域、C/D区域、线性C/D、垂直C/D、平均RNFL厚度、上、下、颞上（TU）、上颞（ST）、上鼻（SN）、鼻上（NU）、鼻下（NL）、下鼻（IN）、下颞（IT）、颞下（TL）象限RNFL厚度。进行方差分析以比较三组之间的差异。两组间比较采用最小显著性差异t检验。结果视盘结构参数：三组间视盘面积差异无统计学意义（F=1.226，P>0.05），其他视盘参数差异有统计学意义（F=5.221，5.586，6.302，5.926，5.319，5.404，5.861，6.603；P 0.05），轻度至中度PD组和重度PD组的IT和TL均小于对照组（P＜0.05），重度PD组患者的平均RNFL、TU、in、IT和TL厚度均小于轻度至中度帕金森病组（P＞0.05）。结论随着PD严重程度的增加，视盘结构和RNFL厚度发生明显变化，表现为视盘面积和体积减小，杯状物面积和体积增大，C/D比明显增大。PD患者的平均RNFL厚度明显薄于对照组，并且在TU和TL象限最明显。关键词：帕金森病；光盘；神经纤维；层析成像，光学相干

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).