Nocturnal Pain Is Not an Alarm Symptom for Upper Gastrointestinal Inflammation but May Be an Indicator of Sleep Disturbance or Psychological Dysfunction

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY
J. Cindrich, Chance S. Friesen, J. Schurman, J. Colombo, C. Friesen
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引用次数: 0

Abstract

Alarm symptoms are widely used in pediatric gastroenterology to discern when abdominal pain needs further workup. Despite wide use, the data supporting the validity of these symptoms are not well established. This study explored one alarm symptom—nighttime waking with pain—and its associations with histologic inflammation of the upper gastrointestinal tract, psychological dysfunction, and disordered sleep. This retrospective study evaluated 240 patients with abdominal pain-related disorders of the gut–brain axis (AP-DGBI). Patients underwent questionnaires related to sleep disturbance, behavioral assessment, and gastrointestinal symptoms, including Rome IV criteria for AP-DGBI. Routine upper endoscopy with standardized biopsies was performed in 205 patients. Endoscopy results showed no association between esophageal, gastric, or duodenal histologic inflammation and nighttime waking with pain. Nocturnal pain was associated with increased scores for both psychological and sleep disorders, including social stress, depression, disorders of initiation and maintenance of sleep (DIMS), disorders of daytime somnolence (DOES), and sleep hyperhidrosis (SHY). This study concluded that nocturnal pain is not a reliable predictor of upper gastrointestinal inflammation but may be a prognosticator for psychological distress and sleep disturbances.
夜间疼痛不是上消化道炎症的警报症状,但可能是睡眠障碍或心理功能障碍的指标
警报症状在儿科胃肠病学中被广泛用于辨别腹痛何时需要进一步检查。尽管使用广泛,但支持这些症状有效性的数据还没有得到很好的证实。这项研究探讨了一种警报症状——夜间醒来时疼痛——及其与上消化道组织炎症、心理功能障碍和睡眠紊乱的关系。这项回顾性研究评估了240名与腹痛相关的肠-脑轴疾病(AP-DGBI)患者。患者接受了与睡眠障碍、行为评估和胃肠道症状相关的问卷调查,包括AP-DGBI的Rome IV标准。对205名患者进行了常规上内镜检查和标准化活检。内窥镜检查结果显示,食道、胃或十二指肠组织学炎症与夜间醒来时疼痛之间没有关联。夜间疼痛与心理和睡眠障碍的得分增加有关,包括社交压力、抑郁、睡眠启动和维持障碍(DIMS)、日间嗜睡障碍(DOS)和睡眠多汗症(SHY)。这项研究得出结论,夜间疼痛不是上消化道炎症的可靠预测因素,但可能是心理困扰和睡眠障碍的预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
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0.00%
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审稿时长
10 weeks
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