Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology Pub Date : 2024-07-01 DOI:10.1016/j.ajur.2023.02.003

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引用次数: 0

Abstract

Objective

Obstructive sleep apnea (OSA) is one of the etiologies of nocturia. We analyzed polysomnography (PSG) results to determine correlated factors related to nocturia in OSA patients with different severity.

Methods

Patients with suspected OSA were examined using PSG. They were divided into two groups based on the presence of nocturia. Nocturia was defined as a patient who needed to void at least once. Apnea–hypopnea index (AHI) was employed to classify patients according to degrees of severity: AHI<5 events/h, 5 events/h≤AHI<15 events/h, 15 events/h≤AHI<30 events/h, and AHI≥30 events/h, defined as normal, mild OSA, moderate OSA, and severe OSA, respectively. Demographic variables, PSG parameters, International Prostate Symptom Scores (IPSSs), and quality of life scores due to urinary symptoms were analyzed.

Results

In total 140 patients, 114 patients had OSA (48 had mild OSA; 34 had moderate OSA; and 32 had severe OSA) and 107 patients had nocturia. The total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA patients. With the increasing severity of OSA, more correlated factors related to nocturia were determined. In mild OSA patients, nocturia related to increased age (p=0.025), minimum arterial blood oxygenation saturation (p=0.046), and decreased AHI of non-rapid eye movement (p=0.047), AHI of total sleep time (p=0.010), and desaturation index (p=0.012). In moderate OSA patients, nocturia related to increased age (p<0.001), awake time (p=0.025), stage 1 sleep (p=0.033), and sleep latency (p=0.033), and decreased height (p=0.044), weight (p=0.025), and sleep efficiency (p=0.003). In severe OSA patients, nocturia related to increased weight (p=0.011), body mass index (p=0.009), awake time (p=0.008), stage 1 sleep (p=0.040), arousal number (p=0.030), arousal index (p=0.013), periodic limb movement number (p=0.013), and periodic limb movement index (p=0.004), and decreased baseline arterial blood oxygenation saturation (p=0.046).

Conclusion

Our study revealed that there were more correlated factors related to nocturia with increasing severity of OSA. This study helps in clinical education and treatment for OSA patients with different severity.

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不同严重程度阻塞性睡眠呼吸暂停患者夜尿对多导睡眠图的影响:一项回顾性观察研究

目的阻塞性睡眠呼吸暂停（OSA）是夜尿症的病因之一。我们分析了多导睡眠图（PSG）结果，以确定不同严重程度的 OSA 患者夜尿的相关因素。方法使用 PSG 对疑似 OSA 患者进行检查，并根据夜尿情况将其分为两组。夜尿的定义是患者至少需要排尿一次。呼吸暂停-低通气指数（AHI）用于根据严重程度对患者进行分类：AHI<5事件/小时、5事件/小时≤AHI<15事件/小时、15事件/小时≤AHI<30事件/小时和AHI≥30事件/小时，分别定义为正常、轻度OSA、中度OSA和重度OSA。分析了人口统计学变量、PSG参数、国际前列腺症状评分（IPSS）以及因泌尿系统症状导致的生活质量评分。结果在总共140名患者中，114名患者有OSA（48名轻度OSA；34名中度OSA；32名重度OSA），107名患者有夜尿症。除重度 OSA 患者组外，其他各组夜尿症患者的总 IPSS 均明显升高。随着 OSA 严重程度的增加，与夜尿相关的因素也越来越多。在轻度OSA患者中，夜尿与年龄增加（P=0.025）、最低动脉血氧饱和度（P=0.046）、非快速眼动AHI下降（P=0.047）、总睡眠时间AHI下降（P=0.010）和不饱和指数下降（P=0.012）有关。在中度 OSA 患者中，夜尿与年龄（p<0.001）、清醒时间（p=0.025）、第一阶段睡眠（p=0.033）和睡眠潜伏期（p=0.033）的增加以及身高（p=0.044）、体重（p=0.025）和睡眠效率（p=0.003）的降低有关。在重度 OSA 患者中，夜尿与体重（p=0.011）、体重指数（p=0.009）、清醒时间（p=0.008）、第一阶段睡眠（p=0.040）、唤醒次数（p=0.030）、唤醒指数（p=0.013）、周期性肢体运动次数（p=0.结论我们的研究显示，随着 OSA 严重程度的增加，与夜尿症相关的因素增多。本研究有助于对不同严重程度的 OSA 患者进行临床教育和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

4.00

自引率

3.80%

发文量

100

审稿时长

4 weeks

期刊介绍： Asian Journal of Urology (AJUR), launched in October 2014, is an international peer-reviewed Open Access journal jointly founded by Shanghai Association for Science and Technology (SAST) and Second Military Medical University (SMMU). AJUR aims to build a communication platform for international researchers to effectively share scholarly achievements. It focuses on all specialties of urology both scientifically and clinically, with article types widely covering editorials, opinions, perspectives, reviews and mini-reviews, original articles, cases reports, rapid communications, and letters, etc. Fields of particular interest to the journal including, but not limited to: • Surgical oncology • Endourology • Calculi • Female urology • Erectile dysfunction • Infertility • Pediatric urology • Renal transplantation • Reconstructive surgery • Radiology • Pathology • Neurourology.