How Various Drug Delivery Methods Could Aid in the Translation of Genome Prime Editing Technologies

IF 1.4 4区生物学 Q4 GENETICS & HEREDITY

Genetics research Pub Date : 2022-02-21 DOI:10.1155/2022/7301825

E. Ivanova

引用次数: 0

Abstract

Drug delivery systems can be engineered to enhance the localization of therapeutics in specific tissues in response to externally applied stimuli and/or local environmental changes. In recent decades, efforts to improve drug delivery techniques at both nano- and macroscale have led to a new era of therapeutic efficacy. Such technological advancements resulted in improved drug delivery systems regularly entering the clinical setting. However, these delivery innovations are unfortunately not always readily applied to newly developed technologies. One of these new and exciting technologies that has been overlooked by drug delivery scientists is prime editing. Prime editing is a novel genome editing technology that exhibits the plug-and-play capability of CRISPR/Cas9 editors while avoiding double-strand DNA breaks throughout the entire process. This article focuses on describing the potential advantages and disadvantages of selecting nanomedicine technologies along with prime editing capabilities for the delivery of cargo.

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不同的药物递送方法如何帮助翻译基因组引物编辑技术

药物递送系统可以被设计为响应于外部施加的刺激和/或局部环境变化来增强治疗剂在特定组织中的定位。近几十年来，在纳米和宏观尺度上改进药物递送技术的努力开创了治疗效果的新时代。这些技术进步导致了药物递送系统的改进，从而定期进入临床环境。然而，不幸的是，这些交付创新并不总是容易应用于新开发的技术。其中一项被药物递送科学家忽视的令人兴奋的新技术是初级编辑。Prime编辑是一种新型的基因组编辑技术，它展示了CRISPR/Cas9编辑器的即插即用能力，同时在整个过程中避免了双链DNA断裂。本文重点描述了选择纳米医学技术的潜在优势和劣势，以及交付货物的主要编辑能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics research 生物-遗传学

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Genetics Research is a key forum for original research on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Our aim is to lead to a better understanding of genetic processes in health and disease. The journal focuses on the use of new technologies, such as next generation sequencing together with bioinformatics analysis, to produce increasingly detailed views of how genes function in tissues and how these genes perform, individually or collectively, in normal development and disease aetiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioural genetics and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians and researchers involved in genetic basis of diseases, evolutionary and developmental studies.