The Clinical Use of Mediator Release Test in Food Sensitivities

Abstract

Food sensitivities are non-IgE-mediated, non-coeliac, dose-dependent and delayed systemic responses to food. They consist of a highly complex class of adverse food reactions; however, their last phase is the release of mediators from leukocytes. The Mediator Release Test (MRT) is a functional measure of sensitivity-based inflammatory responses. It is an end-point test, which can account for the widest range of triggering mechanisms involved in sensitivity reactions, including both innate and adaptive pathways. MRT not only tests reactions to foods, food-chemicals, and other substances, but also reliably quantifies the degree of the inflammatory response. The test opens the new therapeutic options for food sensitivities.