Ace gene polymorphisms are ineffective on contrast induced nephropathy

IF 0.8 Q4 GENETICS & HEREDITY

Meta Gene Pub Date : 2022-02-01 DOI:10.1016/j.mgene.2021.100992

İlhan Kılıç , Orkide Palabıyık , Gökay Taylan , Tammam Sipahi , Sedat Üstündağ

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引用次数: 0

Abstract

Background: The renin–angiotensin system regulates the haemodynamics. ACE gene polymorphisms are known to influence serum angiotensin converting enzyme level. Contrast nephropathy develops after exposure to intravascular contrast media that influence vascular hemodynamics. ACE gene polymorpisms may have an enhancing role in contrast media related renal injury.

The aim of the study: The aim of this study was to investigate the impact of ACE insertion/deletion (I/D) polymorphism in contrast-induced nephropathy (CIN) development.

Methods: 194 patients with chronic kidney disease that were administered iodinated contrast media were examined. Patients were monitored for at least 7 days for CIN development after parenteral contrast exposure. Control and patient groups were divided in terms of CIN development status. Polymerase chain reaction was performed for the genotyping of the ACE gene polymorphism from DNAs that were isolated from peripheral blood of the patients.

Results: 83 patients with CIN (34 women, 49 men) and 111 control patients without CIN (43 women, 68 men) were enrolled. Gender was not statistically different between the two groups (p = 0.75). The average age of the CIN group (71) was greater than that of the control group (68). No association was detected between ACE gene polymorphism (II, ID AND DD genotypes) and CIN in both patients and controls.

Conclusion: ACE gene polymorphisms does not influence contrast induced nephropathy development.

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Ace基因多态性对造影剂肾病无效

背景:肾素-血管紧张素系统调节血流动力学。已知ACE基因多态性影响血清血管紧张素转换酶水平。造影剂肾病是在暴露于影响血管血流动力学的血管内造影剂后发生的。ACE基因多态性可能在造影剂相关性肾损伤中起增强作用。研究目的:本研究的目的是研究ACE插入/缺失(I/D)多态性在造影剂肾病(CIN)发展中的影响。方法:对194例慢性肾脏病患者行碘造影剂检查。在静脉注射造影剂暴露后，对患者进行至少7天的CIN发展监测。根据CIN的发展情况分为对照组和患者组。采用聚合酶链反应对患者外周血中分离的ACE基因多态性进行基因分型。结果:共纳入83例CIN患者(女性34例，男性49例)和111例非CIN对照患者(女性43例，男性68例)。两组患者性别差异无统计学意义(p = 0.75)。CIN组平均年龄(71岁)大于对照组(68岁)。在患者和对照组中均未发现ACE基因多态性(II、ID和DD基因型)与CIN之间的相关性。结论:ACE基因多态性不影响造影剂肾病的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.