Oral administration of triethylenetetramine (TETA) reduces some inflammatory markers in streptozotocin-induced diabetes mellitus in rat

Abstract

Introduction: Owing to harmful effects of inflammatory markers on occurrence and progression of diabetic complications, hence, studying the possible effect of chemical components on these markers seems to be effective in diabetes mellitus. This study aimed to assess whether the triethylenetetramine (TETA), as a copper chelator, affects the plasma level of inflammatory markers such as visfatin (Vis), cholinesterase (CholE), total sialic acid (TSA) and hepcidin (Hep) in streptozotocin- induced diabetes mellitus rat. Materials and methods: Thirty male Wistar rats were assigned for this study. After induction of diabetes mellitus, TETA with different doses (10, 20 and 40 mg/kg/day) was orally administrated for 6 months. Thereupon, the above inflammatory factors were measured in all treatment groups. Results: Plasma concentrations of Vis, CholE, TSA, Hep and glucose decreased significantly (P<0.01) in the highest dose group (40 mg/kg/day) compared with control group. Interestingly, by enhancement of TETA dose, these levels were lowered. Conclusion: The results suggested that TETA administration in the dose of 40 mg/kg/day leads to profound reduction of the inflammatory markers Vis, CholE, TSA and Hep, therefore may have beneficial effect on diabetes mellitus.