Effect of Lymphocyte Immunotherapy on Pro-Inflammatory Th17 Related Cytokine Levels in Women with Recurrent Spontaneous Abortion

dnshnmh Srm Pub Date : 2019-03-01 DOI:10.29252/sjrm.4.1.59

A. Zare, A. Saremi, P. Salehian, N. Roomandeh, M. Naderi, P. Lashgari, J. Arasteh, P. Kokhaei

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引用次数: 2

Abstract

[23] Induction of MLR-Bf and protection of fetal ... [24] Lymphocyte immunotherapy and its probable mechanism ... [25] Possible mechanisms of immunotherapy for maintaining pregnancy ... [26] Association of human leucocyte antigen sharing with ... [27] Diagnosis and treatment of recurrent miscarriage ... [28] The influence of paternal lymphocyte ... [29] Alteration of Th17 and Treg cells in patients with unexplained ... [30] Correlation between serum zinc levels and successful immunotherapy ... [31] Cytokines in recurrent pregnancy ... [32] Characteristics of immune cell changes ... [33] Natural killer cells promote immune ... [34] Alteration of TH1 and TH2 cells by intracellular cytokine ... [35] The deregulation of regulatory T cells on interleukin-17-producing T ... [36] Proportional change of CD4+CD25+ regulatory T cells in ... [37] An imbalance in interleukin-17-producing T and ... [38] Intravenous immunoglobulin G modulates peripheral ... [39] The basis and value of currently used ... [40] Effect of leukocyte therapy ... [41] Comprehensive analysis of peripheral blood ... [42] Study on the relationship between Th17 cells ... [43] Genetic variations in the interleukin-21 ... [44] Th17 cells and related cytokines in unexplained ... levels of IL-17and IL-21 in patient serum and supernatant of cultured peripheral blood mononuclear cells were assayed before and after this treatment by using ELISA. Statistical analysis was performed with Wilcoxon test by SPSS 22. Findings The levels of IL-17and IL-21 in patient serum after immunotherapy were significantly decreased (p<0.05). Supernatant of cultured peripheral blood mononuclear cells after immunotherapy showed a low level of IL-21 (p<0.04), while this change was not significant for interleukin 17 (p=0.13). Conclusion Lymphocyte immunotherapy reduces the level of pro-inflammatory cytokines of Th17 cells in women with recurrent spontaneous abortion.

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淋巴细胞免疫治疗对复发性自然流产妇女促炎性Th17相关细胞因子水平的影响

[23]MLR-Bf的诱导和对胎儿的保护。。。[24]淋巴细胞免疫疗法及其可能机制。。。[25]免疫疗法维持妊娠的可能机制。。。[26]人类白细胞抗原共享与。。。[27]反复流产的诊断和治疗。。。[28]父亲淋巴细胞的影响。。。[29]不明原因…患者Th17和Treg细胞的变化。。。[30]血清锌水平与免疫治疗成功之间的相关性。。。[31]复发性妊娠中的细胞因子。。。[32]免疫细胞变化的特征。。。[33]自然杀伤细胞促进免疫。。。[34]细胞内细胞因子对TH1和TH2细胞的改变。。。[35]调节性T细胞对产生白细胞介素-17的T。。。[36]CD4+CD25+调节性T细胞在。。。[37]白细胞介素17产生的T和。。。[38]静脉注射免疫球蛋白G调节外周。。。[39]当前使用的。。。[40]白细胞治疗的效果。。。[41]外周血综合分析。。。[42]研究Th17细胞与。。。[43]白细胞介素-21的遗传变异。。。[44]Th17细胞和相关细胞因子在不明原因的。。。用ELISA法测定治疗前后患者血清和培养的外周血单核细胞上清液中IL-17和IL-21的水平。统计分析采用SPSS 22软件进行Wilcoxon检验。结果免疫治疗后患者血清中IL-17和IL-21水平显著降低（p<0.05），结论淋巴细胞免疫治疗可降低复发性自然流产妇女Th17细胞的促炎细胞因子水平。

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dnshnmh Srm

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15 weeks