The Association of Gene Polymorphisms Linked to Caffeine Use with Athletic Performance

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
PhD. Celal Bulgay, Kafein Kullanimina, Etki Eden, Gen Polimorfizmlerinin, Atletik Performans, İle İli̇şki̇si̇, Selin Yildirim, Mehmet Ali Ergun, Özgür Eken, H. İ. Ceylan, Hadi Nobari, M. Cerit
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引用次数: 0

Abstract

Caffeine's use as a performance-enhancing supplement among professional athletes progressively increased after it was taken off the World Anti-Doping Agency's (WADA) list of banned substances. The present review looks at the interactions caused by different levels of caffeine ergogenicity in athletes and gene polymorphisms that affect caffeine ergogenic effect in the current literature. Therefore, a comprehensive analysis of the studies available in the literature and the respective study results have evaluated caffeine ergogenicity in athletes and gene polymorphisms. The search for studies was performed through five databases. Individual responses to caffeine consumption may differ from person to person due to multigene and multifactorial interactions. Adenosine A2A receptor ( ADORA2A ) and Cytochrome P450 1A2 ( CYP1A2 ) are two genes thought to have the most effects on caffeine's ergogenicity. The function of these two genes accounts for most inter-individual variations in studies after caffeine ingestion. Based on the findings, it is understood that the contribution of caffeine use to individual performance development varies over time due to changes in both environmental and epigenetic interactions, as well as parameters such as circadian rhythm, training loads, nutritional routine, habitual caffeine use, drug intake, expectation, time of consumption, and heredity. As a result, individual caffeine responses are highly complex and involve multiple modifiers.
咖啡因使用与运动表现相关的基因多态性
咖啡因从世界反兴奋剂机构(WADA)的禁用物质名单中删除后,职业运动员将其作为提高成绩的补充剂的使用量逐渐增加。本综述着眼于运动员中不同水平的咖啡因麦角性引起的相互作用,以及当前文献中影响咖啡因麦角效应的基因多态性。因此,对文献中可用的研究和各自的研究结果进行综合分析,评估了咖啡因在运动员中的麦角性和基因多态性。研究搜索通过五个数据库进行。由于多基因和多因素的相互作用,个体对咖啡因摄入的反应可能因人而异。腺苷A2A受体(ADORA2A)和细胞色素P4501A2(CYP1A2)是被认为对咖啡因的麦角性影响最大的两个基因。这两个基因的功能解释了摄入咖啡因后研究中大多数个体间变异的原因。根据研究结果,可以理解,由于环境和表观遗传学相互作用的变化,以及昼夜节律、训练负荷、营养习惯、习惯性咖啡因使用、药物摄入、预期、消费时间和遗传等参数的变化,咖啡因使用对个人表现发展的贡献会随着时间的推移而变化。因此,个体对咖啡因的反应是高度复杂的,涉及多种调节剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gazi Medical Journal
Gazi Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.30
自引率
0.00%
发文量
105
审稿时长
16 weeks
期刊介绍: Gazi Medical Journal is being published from 1990 four times annually. Gazi Medical Journal is an international journal presenting research results in all medical fields, with the aim of becoming the premier source of high quality research from Eastern Europe , Middle East and Asia. The Gazi Medical Journal is peer-reviewed and is published quarterly in paper and electronic version. The language of the Gazi Medical Journal is English and Turkish. Offerings include research articles, rapid communications, case reports, letters to the editor, meta-analyses and commentaries
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