A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease

Q3 Medicine

Nutrition and Healthy Aging Pub Date : 2023-04-25 DOI:10.3233/nha-220190

B. Rauchmann, Patrizia Gross, Ersin Ersoezlue, Michael Wagner, Ballarini Tommaso, C. Kurz, M. Tatò, J. Utecht, B. Papazov, S. Guersel, Marie Totzke, L. Trappmann, L. Burow, G. Koller, S. Stöcklein, D. Keeser, S. Altenstein, C. Bartels, K. Buerger, P. Dechent, L. Dobisch, M. Ewers, K. Fliessbach, S. D. Freiesleben, W. Glanz, Doreen Goeerss, D. Gref, J. Haynes, D. Janowitz, I. Kilimann, O. Kimmich, L. Kleineidam, C. Laske, A. Lohse, F. Maier, C. Metzger, M. Munk, O. Peters, L. Preis, J. Priller, S. Roeske, N. Roy, C. Sanzenbacher, K. Scheffler, A. Schneider, B. Schott, A. Spottke, E. Spruth, S. Teipel, D. M. van Lent, J. Wiltfang, S. Wolfsgruber, R. Yakupov, E. Düzel, F. Jessen, R. Perneczky

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引用次数: 0

Abstract

BACKGROUND: There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequent use. OBJECTIVE: Here we aimed to validate a 6-items short questionnaire for a Mediterranean-like diet (6-QMD) and explore its associations with memory performance and hippocampal atrophy in healthy elders and individuals at risk for AD. METHODS: We analyzed 938 participants (N = 234 healthy controls and N = 704 participants with an increased AD risk) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). The 6-QMD was validated against the Mediterranean Diet (MeDi) score and the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, both derived from a detailed FFQ. Furthermore, associations between the 6-QMD and memory function as well as hippocampal atrophy were evaluated using linear regressions. RESULTS: The 6-QMD was moderately associated with the FFQ-derived MeDi adherence score (ρ = 0.25, p < 0.001) and the MIND score (ρ = 0.37, p= < 0.001). Higher fish and olive oil consumption and lower meat and sausage consumption showed significant associations in a linear regression, adjusted for diagnosis, age, sex and education, with memory function (β = 0.1, p = 0.008) and bilateral hippocampal volumes (left: β = 0.15, p < 0.001); (right: β = 0.18, p < 0.001)). CONCLUSIONS: The 6-QMD is a useful and valid brief tool to assess the adherence to MeDi and MIND diets, capturing associations with memory function and brain atrophy in healthy elders and individuals at increased AD dementia risk, making it a valid alternative in settings with time constraints.

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一份包含6个项目的问卷(6-QMD)记录了地中海式饮食模式，并与老年人和阿尔茨海默病风险人群的记忆表现和海马体体积有关

背景：有证据表明，坚持地中海式饮食可以减少阿尔茨海默病（AD）患者的认知能力下降和脑萎缩。然而，冗长的饮食评估，如食物频率问卷（FFQ），阻碍了更频繁的使用。目的：在这里，我们旨在验证地中海式饮食（6-QMD）的6项简短问卷，并探讨其与健康老年人和AD风险个体的记忆表现和海马萎缩的关系。方法：我们分析了来自DZNE纵向认知障碍和痴呆症研究（DELCODE）的938名参与者（N=234名健康对照组和N=704名AD风险增加的参与者）。6-QMD根据地中海饮食（MeDi）评分和地中海DASH饮食干预神经退行性延迟（MIND）评分进行验证，这两项评分均来自详细的FFQ。此外，使用线性回归评估6-QMD与记忆功能以及海马萎缩之间的关系。结果：6-QMD与FFQ衍生的MeDi依从性评分（ρ=0.25，p<0.001）和MIND评分（ρ=0.037，p=0.001）适度相关。较高的鱼类和橄榄油消费量以及较低的肉类和香肠消费量在线性回归中显示出显著的相关性，经诊断、年龄、性别和教育程度调整后，记忆功能（β=0.1，p=0.008）和双侧海马体积（左：β=0.15，p<0.001）；（右：β=0.18，p<0.001）。结论：6-QMD是评估MeDi和MIND饮食依从性的有用而有效的简短工具，可以捕捉健康老年人和AD痴呆风险增加的个体与记忆功能和脑萎缩的关系，使其成为时间限制环境中的有效替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Healthy Aging Agricultural and Biological Sciences-Food Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.