Radioprotective potential of some medicines used in Tabuk, Saudi Arabia, to minimise the effects of the ionising radiations

Q4 Energy

International Journal of Nuclear Energy Science and Technology Pub Date : 2017-11-21 DOI:10.1504/IJNEST.2017.10009081

M. I. Sayyed

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引用次数: 0

Abstract

With increasing use of ionising radiations (in particular the gamma rays and X-rays) in medicine, many dangerous diseases may occur. Hence, it is necessary to restrict and control exposure of human beings to these radiations. In this study we have investigated the radioprotective effectiveness of some medications sold at community pharmacies in Tabuk, Saudi Arabia. The data were collected and recorded for 20 drugs commonly used for different medical purposes. In order to investigate the effectiveness of these radioprotectives in terms of absorption of low and high energy photons, the effective atomic number (Zeff) of ten drugs for total photon interaction in the energy range of 1 keV to 15 MeV using WinXCom were calculated. In addition, by Geometric-Progression (G-P) method, the energy absorption (EABF) and exposure build-up factors (EBF) for incident photon energy 0.015 MeV to 15 MeV up to penetration depths of 40 mean free paths (mfp) were calculated for the ten drugs. Among the selected compounds, Captopril and Cefixime have the maximum value of Zeff, while the minimum EBF and EABF were found for Mesna, Cramastine, Thiotepa and Busflan; therefore, they are appealing as radioprotective compounds.

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沙特阿拉伯塔布克使用的一些药物的辐射防护潜力，以尽量减少电离辐射的影响

随着电离辐射（特别是伽马射线和X射线）在医学中的使用越来越多，许多危险的疾病可能会发生。因此，有必要限制和控制人类接触这些辐射。在这项研究中，我们调查了沙特阿拉伯塔布克社区药店出售的一些药物的辐射防护效果。收集并记录了20种常用于不同医疗目的的药物的数据。为了研究这些放射性保护剂在吸收低能和高能光子方面的有效性，使用WinXCom计算了10种药物在1keV至15MeV能量范围内的总光子相互作用的有效原子序数（Zeff）。此外，通过几何级数（G-P）方法，计算了10种药物的能量吸收（EABF）和暴露累积因子（EBF），入射光子能量为0.015MeV至15MeV，穿透深度为40个平均自由程（mfp）。在所选化合物中，卡托普利和头孢克肟的Zeff值最大，而梅斯那、克拉玛汀、Thiotepa和Busflan的EBF和EABF值最小；因此，它们作为放射性保护化合物很有吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nuclear Energy Science and Technology Energy-Nuclear Energy and Engineering

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Today, nuclear reactors generate nearly one quarter of the electricity in nations representing two thirds of humanity, and other nuclear applications are integral to many aspects of the world economy. Nuclear fission remains an important option for meeting energy requirements and maintaining a balanced worldwide energy policy; with major countries expanding nuclear energy"s role and new countries poised to introduce it, the key issue is not whether the use of nuclear technology will grow worldwide, even if public opinion concerning safety, the economics of nuclear power, and waste disposal issues adversely affect the general acceptance of nuclear power, but whether it will grow fast enough to make a decisive contribution to the global imperative of sustainable development.