Osteoplastic Material Based on a Bone Matrix Resistant to Osteoclastic Resorption under Conditions of a Pronounced Regenerative Process as a Carrier for rhBMP

IF 0.5 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Inorganic Materials: Applied Research Pub Date : 2022-07-19 DOI:10.1134/S2075113322040244

Yu. S. Lukina, B. P. Mishchenko, V. V. Zaytsev, M. G. Vasilev, I. I. Selezneva

引用次数: 1

Abstract

A technology has been developed for obtaining and evaluating in model studies in vitro a chemically fixed xenogenic bone matrix structurally resistant to osteoclastic resorption. The parameters of demineralization of the fragmented bone matrix have been selected in which the complete removal of the mineral component is carried out with the preservation of collagen in its native state. Optimal technological parameters of chemical fixation with epoxy compounds make it possible to obtain a stable material with free epoxy groups which can serve as a carrier for recombinant protein growth factors (rhBMP) in conditions of a pronounced regenerative process.

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在明显再生过程条件下，基于骨基质的抗破骨细胞吸收的骨塑材料作为rhBMP的载体

已经开发了一种技术，用于体外模型研究中获得和评估化学固定的具有抗破骨细胞吸收结构的异种骨基质。破碎骨基质脱矿的参数已被选择，其中矿物成分的完全去除是在其天然状态下保存胶原蛋白。通过优化环氧化合物化学固定的工艺参数，可以获得具有游离环氧基团的稳定材料，该材料可以在明显的再生过程中作为重组蛋白生长因子(rhBMP)的载体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inorganic Materials: Applied Research Engineering-Engineering (all)

CiteScore

0.90

自引率

0.00%

发文量

199

期刊介绍： Inorganic Materials: Applied Research contains translations of research articles devoted to applied aspects of inorganic materials. Best articles are selected from four Russian periodicals: Materialovedenie, Perspektivnye Materialy, Fizika i Khimiya Obrabotki Materialov, and Voprosy Materialovedeniya and translated into English. The journal reports recent achievements in materials science: physical and chemical bases of materials science; effects of synergism in composite materials; computer simulations; creation of new materials (including carbon-based materials and ceramics, semiconductors, superconductors, composite materials, polymers, materials for nuclear engineering, materials for aircraft and space engineering, materials for quantum electronics, materials for electronics and optoelectronics, materials for nuclear and thermonuclear power engineering, radiation-hardened materials, materials for use in medicine, etc.); analytical techniques; structure–property relationships; nanostructures and nanotechnologies; advanced technologies; use of hydrogen in structural materials; and economic and environmental issues. The journal also considers engineering issues of materials processing with plasma, high-gradient crystallization, laser technology, and ultrasonic technology. Currently the journal does not accept direct submissions, but submissions to one of the source journals is possible.