Correction of cognitive-mnestic dysfunction of rats after ketamine anesthesia under the influence of heteroside

Abstract

Today, in medical practice, a very promising direction of development can be the expansion of the range of primary and secondary neuroprotection drugs through the use of targeted synthesis of potential neuroprotective agents with analeptic effect. This is necessary to improve anesthetic safety during surgery and to alleviate post-anesthetic intoxication after anesthesia. Therefore, the aim of our study was to compare the neuroprotective activity of original derivatives of sulfur and nitrogen-containing heterocycles (heterosides) and reference drugs, which are already known in pharmacology (cerebroprotective agent with neurotrophic action ¾ cerebrocurin and nootropic drug with neuroprotective action ¾ noopept). In the course of the research, it was found that after ketamine anesthesia, the excitability of the central nervous system increases, the anxious behavior of animals increases, while the indicators of the research work of animals in the experiment sharply deteriorate. After 2 days or more (10 days) after the transferred ketamine anesthesia, a deterioration in mnestic functions was noted in this group of animals. With the introduction of 100 mg / kg of heteroside to a group of rats after ketamine anesthesia, the indicators of anxiety behavior and excitability of animals significantly decreased, their research activity increased, a pronounced antiamnestic effect was manifested, and the ability of animals to learn was increased as well. It also turned out that in terms of the degree of influence on the indicators of the cognitive-mnestic functions of the central nervous system, heteroside statistically significantly exceeds the comparison drugs cerebrocurin and noopept, which in turn showed high efficiency in reducing anxiety of animals, and also had an antiamnestic effect, but did not affect the ability of animals to learn.