Effect of NB-UVB therapy on IL-6 and neopterin levels in patients with psoriasis

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2023-01-01 DOI:10.1515/pteridines-2022-0048

E. Şahin, Sonia Sanajou, G. Girgin, T. Akan, T. Baydar

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引用次数: 1

Abstract

Abstract Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferation in the skin. Dysregulation of the immune system is an important factor in this pathology. Inflammation markers, pro-inflammatory cytokines, and immune cells are reported to be changed in psoriasis. Study design In the current cohort study, the possible changes in interleukin-6 (IL-6), neopterin levels, and kynurenine (Kyn) pathway in 42 psoriasis patients compared to 30 controls, and their change with narrow-band (NB) UVB treatment were investigated. Methodology IL-6 and serum neopterin levels were analyzed with ELISA kits. HPLC analyses were performed to detect urinary neopterin, serum Kyn, and tryptophan (Trp) levels. Results IL-6 levels were lower, while Kyn levels and the Kyn-to-Trp ratio were higher in psoriasis patients compared to control subjects (p < 0.01, all). Conclusion Narrow-band ultraviolet B (NB-UVB) treatment decreased Psoriasis Area and Severity Index (PASI) scores and increased urinary neopterin levels of the patients (both, p < 0.01). Serum neopterin was correlated with Kyn and Kyn/Trp levels before and after NB-UVB treatment (p < 0.05, all). These findings point out that the measured parameters might be considered to support the PASI score in both diagnosis and prognosis of psoriasis rather than evaluating the severity of the disease.

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NB-UVB治疗对银屑病患者IL-6和新蝶呤水平的影响

背景银屑病是一种慢性非短暂性疾病，伴有皮肤表皮增生增加。免疫系统失调是这种病理的一个重要因素。据报道，炎症标志物、促炎细胞因子和免疫细胞在牛皮癣中发生了变化。在本队列研究中，研究了42例银屑病患者与30例对照组相比，白细胞介素-6 (IL-6)、新蝶呤(neopterin)水平和犬尿氨酸(Kyn)途径可能发生的变化，以及它们在窄带(NB) UVB治疗后的变化。方法采用ELISA试剂盒分析血清IL-6和新蝶呤水平。采用高效液相色谱法检测尿中新蝶呤、血清Kyn和色氨酸水平。结果银屑病患者IL-6水平低于对照组，Kyn水平及Kyn /色氨酸比值高于对照组(p均< 0.01)。结论窄带紫外线B (NB-UVB)治疗可降低患者银屑病面积及严重程度指数(PASI)评分，提高尿新蝶呤水平(p < 0.01)。NB-UVB治疗前后血清neopterin与Kyn、Kyn/色氨酸水平相关(p < 0.05)。这些发现表明，测量参数可能被认为在银屑病的诊断和预后方面支持PASI评分，而不是评估疾病的严重程度。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.