{"title":"Effects of boron exposure on human reproduction and development","authors":"Yalçın Duydu , Nurşen Başaran","doi":"10.1016/j.cotox.2023.100403","DOIUrl":null,"url":null,"abstract":"<div><p><span>Boric acid<span> and sodium borates are classified as toxic to reproduction under category 1B, with the hazard statement of H360FD in the EU-CLP regulation. This classification has triggered occupational epidemiology studies on boron (B) in countries with high boron reserves, especially in China and Türkiye. The highest mean total daily B exposure (DBE) levels in mining areas or processing plants of China and Türkiye were 41.2 and 47.17 mg/day respectively. Despite these reported high exposure levels in occupational settings, B-mediated reproductive effects have not been observed. The highest mean blood-boron concentrations (BBC) reported for the B exposed workers in these countries, are still much lower than the BBC corresponding to the NOAEL for reproductive effects in rats. The current epidemiological studies have proven that it will not be possible to reach the critical BBC in humans for the reproductive and </span></span>developmental effects, especially in daily life.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"34 ","pages":"Article 100403"},"PeriodicalIF":6.1000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202023000189","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Boric acid and sodium borates are classified as toxic to reproduction under category 1B, with the hazard statement of H360FD in the EU-CLP regulation. This classification has triggered occupational epidemiology studies on boron (B) in countries with high boron reserves, especially in China and Türkiye. The highest mean total daily B exposure (DBE) levels in mining areas or processing plants of China and Türkiye were 41.2 and 47.17 mg/day respectively. Despite these reported high exposure levels in occupational settings, B-mediated reproductive effects have not been observed. The highest mean blood-boron concentrations (BBC) reported for the B exposed workers in these countries, are still much lower than the BBC corresponding to the NOAEL for reproductive effects in rats. The current epidemiological studies have proven that it will not be possible to reach the critical BBC in humans for the reproductive and developmental effects, especially in daily life.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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