Polycystic ovary syndrome and immune deregulation: what do hormones want to say?

Betcy Susan Johnson, M. Laloraya
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引用次数: 0

Abstract

Polycystic ovary syndrome (PCOS) is one of the most frequently observed endocrinopathies among women of reproductive age that redound to subfertility. The specific etiology of this heterogenic syndrome remains ambiguous. Metabolic complications, hormonal imbalance, deregulation in the immune system and their interrelationship make PCOS more complex. Hyperandrogenism and chronic low-grade inflammation modulate each other and enhance the self-perpetuation of PCOS. Even though there are many literature studies on PCOS and immune deregulation, this review focuses on the endocrine-immune nexus and how the altered endocrine system is embroiled in the immunopathology of PCOS.
多囊卵巢综合征与免疫失调:激素想说什么?
多囊卵巢综合征(PCOS)是育龄妇女中最常见的内分泌疾病之一,会导致生育能力低下。这种异质性综合征的具体病因尚不明确。代谢并发症、激素失衡、免疫系统失调及其相互关系使多囊卵巢综合征更加复杂。雄激素过度和慢性低度炎症相互调节,增强多囊卵巢综合征的自我延续。尽管有许多关于多囊卵巢综合征和免疫失调的文献研究,但这篇综述的重点是内分泌-免疫关系,以及改变的内分泌系统如何参与多囊卵巢综合症的免疫病理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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