HYPERLIPIDEMIA CONNOTED VITIATION OF SERUM ADIPOKINES AND REDOX IMBALANCES

Abstract

Background and objectives: Atherosclerosis is the underlying pathology of ischemic heart disease. There are many aggravating metabolic and oxidant parameters which are participating together overwhelming the pathology of vascular stenosis. Adipokines play a positive metabolic effect in healthy individuals and oxidation reaction greatly impacts the lipid metabolism and might negatively impact the condition. In the present study, we aimed to characterize the level of adiponectin, obestatin, and redox parameters in atherosclerotic patients. Methods: Serum was collected from atherosclerotic patients and froze to be ready for analysis. Results: The results indicated that hyperlipidemia significantly reduced adiponectin, obestatin, and antioxidant enzymes (catalase, glutathione, glutathione-S-transferase, and glutathione peroxidase) together with a significant increase in oxidant byproduct (malondialdehyde) and modulated lipid parameters (cholesterol, triglyceride, and high-density lipoprotein). Conclusion: The study concluded that atherosclerosis is associated with reduced antioxidant enzymes, obestatin, and adiponectin levels and increased lipid levels. These parameters play a great role in the patho-logical status of coronary stenosis