Research progress in effect of alendronate on healing of osteoporotic fracture

中华创伤杂志 Pub Date : 2020-01-15 DOI:10.3760/CMA.J.ISSN.1001-8050.2020.01.013

Yajun Wang, Chen Xiao, Xinli Zhi, S. Jiacan

引用次数: 1

Abstract

Fracture healing is a complex physiological process involving osteoblasts, osteoclasts and other cells and molecules. Typical fracture healing can be divided into four stages: inflammatory response, soft callus formation, hard callus formation, and bone remodeling. Osteoclasts play a leading role in hard callus formation and bone remodeling. Alendronate can inhibit osteoclast activity and bone loss in patients with osteoporosis, but it may also inhibit fracture healing. Therefore, whether alendronate can be used after osteoporotic fracture is controversial. In recent years, it has been found that alendronate can not affect the fracture healing, but also reduce the risk of secondary fracture and improve the prognosis of patients. In this article, the mechanism of alendronate and its effect on osteoporotic fracture healing by systemic and local use are reviewed, which can provide a reference for clinical selection of therapeutic drugs. Key words: Osteoporotic fractures; Fracture healing; Alendronate

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阿仑膦酸钠对骨质疏松性骨折愈合作用的研究进展

骨折愈合是一个复杂的生理过程，涉及到成骨细胞、破骨细胞和其他细胞和分子。典型的骨折愈合可分为四个阶段:炎症反应、软骨痂形成、硬骨痂形成和骨重塑。破骨细胞在硬骨痂形成和骨重塑中起主导作用。阿仑膦酸钠可以抑制骨质疏松症患者的破骨细胞活性和骨质流失，但也可能抑制骨折愈合。因此，在骨质疏松性骨折后是否可以使用阿仑膦酸钠存在争议。近年来研究发现，阿仑膦酸钠不仅不影响骨折愈合，还能降低患者继发骨折的风险，改善患者预后。本文就阿仑膦酸钠的作用机制及全身和局部应用对骨质疏松性骨折愈合的影响进行综述，为临床选择治疗药物提供参考。关键词:骨质疏松性骨折;骨折愈合;Alendronate

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华创伤杂志

自引率

0.00%

发文量

11327

期刊介绍： Chinese Journal of Trauma (International Standard Serial Publication Number: ISSN 1001-8050, Domestic Uniform Serial Publication Number: CN 50-1098/R) was founded in September 1985, which is the only high-level medical professional academic journal that can comprehensively and systematically reflect the achievements and development trends of China's traumatology medicine, and has a wide academic influence in China's traumatology medicine community. It has a wide range of academic influence in China's trauma medicine. Chinese Journal of Trauma is a source journal of China Science and Technology Paper Statistics, a source journal of China Science Citation Database (CSCD), a core journal of China Comprehensive Medicine and Health Care, a source journal of China Academic Journals Comprehensive Evaluation Database (CAJCED), a full-text journal of China Journal Full-text Database (CJFD), a core academic journal of China Center for Scientific Evaluation (RCCSE), a core academic journal of China Traumatology and Traumatology Center (CTC), a core academic journal of China Traumatology Center (RCCSE). RCCSE) core academic journals; Chinese Biomedical Journal Database (CMCC), Chinese Biomedical Journal Citation Database (CBJCED), China Journal Network (CJN), China Academic Journals (CD-ROM), Chinese Academic Journals Abstracts (Chinese Edition), Chemical Abstracts of the United States (CA), Index Copernicus of Poland (IC), and Japan Institute of Science and Technology Database (JICST), World Health Organization Western Pacific Region Medical Search (WPRIM) and Russian Journal of Abstracts (ΡЖ) included journals.