Analysis of clinical application of ALPPS for hepatocellular carcinoma with mild-to-moderate liver cirrhosis

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2019.11.002

Li Chunhong, Deng Mingwu, Qiu Siyuan, Zhu Hongtao, Xu Bangren, Hong Xiaoming, Ji-hua Ren, Wu Guoji, Chen Zhi-ren, Zhang Dantu, Lu Chongmao

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引用次数: 0

Abstract

Objective To study the application of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in hepatocellular carcinoma with mild-to-moderate liver cirrhosis. Methods There are 14 patients with hepatocellular carcinoma underwent ALPPS at the Department of Hepatobiliary and Pancreatic Surgery, Hong Kong University-Shenzhen Hospital from April 2014 to December 2017. The clinical data was retrospectively studied. The studying objects consisted of 9 males and 5 females, aged from 26 to 71 years old with the average age of 51, all cases were of Child-Pugh grade A. The degree of liver cirrhosis, operation and postoperative complications were analyzed. Results All 14 patients completed the ALPPS, 1 patient died post stage 2 operation with liver failure. Comparing the groups with no liver cirrhosis (n=4) with the groups of mild liver cirrhosis (n=5) and moderate liver cirrhosis (n=5), the future liver remnant liver volume growth rates were 58%, 46% and 45.6%, respectively. The average operation intervals were 9.0, 11.2 and 12.8 days, respectively. Postoperative complications occurred in 4 patients: 2 patients with liver failure, 1 patient with intestinal obstruction, and 1 patient with hepatic ascites. Conclusion ALPPS for Child-Pugh grade A, hepatocellular carcinoma with mild-to-moderate liver cirrhosis treatment is safe and feasible. Key words: Liver cirrhosis; Carcinoma, hepatocelluar; Hepatectomy; Associating liver partition and portal vein ligation for staged hepatectomy

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ALPPS治疗肝癌合并轻中度肝硬化的临床应用分析

目的探讨联合肝分区门静脉结扎在肝细胞癌合并轻中度肝硬化的分期肝切除术中的应用。方法选取2014年4月至2017年12月在香港大学-深圳医院肝胆胰外科行肝细胞癌ALPPS治疗的14例患者。回顾性分析临床资料。研究对象男9例，女5例，年龄26 ~ 71岁，平均年龄51岁，均为Child-Pugh a级，分析肝硬化程度、手术情况及术后并发症。结果14例患者均完成了ALPPS, 1例患者在二期手术后因肝功能衰竭死亡。无肝硬化组(n=4)与轻度肝硬化组(n=5)、中度肝硬化组(n=5)比较，未来肝残肝体积增长率分别为58%、46%和45.6%。平均手术间隔分别为9.0、11.2和12.8 d。术后出现并发症4例，其中肝功能衰竭2例，肠梗阻1例，肝性腹水1例。结论ALPPS治疗Child-Pugh A级肝癌合并轻中度肝硬化是安全可行的。关键词:肝硬化;癌,hepatocelluar;肝切除术;联合肝分区和门静脉结扎在分期肝切除术中的应用

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.