Exosome-derived miRNAs regulate macrophage-colorectal cancer cell cross-talk during aggressive tumor development

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2023-03-15 DOI:10.2217/crc-2022-0012

Khandu Wadhonkar, Neha Singh, F. Heralde, S. P. Parihar, N. Hirani, M. Baig

引用次数: 1

Abstract

Colorectal cancer is one of the leading causes of death worldwide. Its incidence and mortality have significantly increased during the past few years. Colorectal cancer cells cross-talk with other cells through exosomes in their tumor microenvironment. The miRNAs containing exosomes are responsible for tumor growth, invasion, and metastasis. Multiple studies have shown that exosomal miRNAs are key players in the crosstalk between cancerous, immune, and stromal cells during colorectal cancer development. They help in the establishment of the tumorigenic microenvironment by reprogramming macrophages towards a pro-tumorigenic phenotype. In this review, we discussed various exosomal miRNAs derived both from colorectal cancer cells and macrophages that promote or inhibit cancer aggression. We also discussed various miRNA-based therapeutic approaches to inhibit cancer progression.

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外源性miRNA在侵袭性肿瘤发展过程中调节巨噬细胞与癌症细胞的串扰

癌症是全球主要的死亡原因之一。在过去几年中，其发病率和死亡率显著增加。结直肠癌癌症细胞通过肿瘤微环境中的外泌体与其他细胞相互交流。含有miRNA的外泌体负责肿瘤的生长、侵袭和转移。多项研究表明，在结直肠癌癌症发展过程中，外泌体miRNA是癌细胞、免疫细胞和基质细胞之间相互作用的关键。它们通过将巨噬细胞重新编程为促肿瘤表型来帮助建立致瘤微环境。在这篇综述中，我们讨论了来自结直肠癌癌症细胞和巨噬细胞的各种外泌体miRNA，它们促进或抑制癌症侵袭。我们还讨论了各种基于miRNA的治疗方法来抑制癌症的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.